Chang Shu-Jun, Hung Shih-Yen, Liu Yan-Lin, Jiang Shiang-Huei
Institute of Nuclear Engineering and Science, National Tsing Hua University, Hsinchu, Taiwan.
Health Physics Division, Institute of Nuclear Energy Research, Atomic Energy Council, Taoyuan, Taiwan.
PLoS One. 2016 Sep 12;11(9):e0162359. doi: 10.1371/journal.pone.0162359. eCollection 2016.
In the internal dose evaluation, the specific absorbed fraction (SAF) and S-value are calculated from the reference phantom based on Caucasian data. The differences in height and weight between Caucasian and Asian may lead to inaccurate dose estimation. In this study, we developed the Taiwanese reference phantoms. 40 volunteers were recruited. Magnetic resonance images (MRI) were obtained, and the contours of 15 organs were drawn. The Taiwanese reference man (TRM) and Taiwanese reference woman (TRW) were constructed. For the SAF calculation, the differences in the self-absorption SAF (self-SAF) between the TRM, TRW, and Oak Ridge National Laboratory (ORNL) adult phantom were less than 10% when the difference in organ mass was less than 20%. The average SAF from liver to pancreas of TRM was 38% larger than that of the ORNL adult phantom, and the result of TRW was 2.02 times higher than that of the ORNL adult phantom. For the S-value calculation, the ratios of TRW and ORNL adult phantom ranged from 0.91 to 1.57, and the ratios of TRM and ORNL adult phantom ranged from 1.04 to 2.29. The SAF and S-value results were dominantly affected by the height, weight, organ mass, and geometric relationship between organs. By using the TRM and TRW, the accuracy of internal dose evaluation can be increased for radiation protection and nuclear medicine.
在内部剂量评估中，特定吸收分数（SAF）和S值是根据白种人数据从参考体模计算得出的。白种人和亚洲人在身高和体重上的差异可能导致剂量估算不准确。在本研究中，我们开发了台湾参考体模。招募了40名志愿者。获取了磁共振图像（MRI），并绘制了15个器官的轮廓。构建了台湾参考男性（TRM）和台湾参考女性（TRW）。对于SAF计算，当器官质量差异小于20%时，TRM、TRW与橡树岭国家实验室（ORNL）成人体模之间的自吸收SAF（self-SAF）差异小于10%。TRM从肝脏到胰腺的平均SAF比ORNL成人体模大38%，TRW的结果比ORNL成人体模高2.02倍。对于S值计算，TRW与ORNL成人体模的比值范围为0.91至1.57，TRM与ORNL成人体模的比值范围为1.04至2.29。SAF和S值结果主要受身高、体重、器官质量以及器官之间的几何关系影响。通过使用TRM和TRW，可提高辐射防护和核医学中内部剂量评估的准确性。
