Azimi Iman, Monteith Gregory R
The School of PharmacyThe University of Queensland, Brisbane, Queensland, Australia.
Mater Research InstituteThe University of Queensland, Brisbane, Queensland, Australia.
Endocr Relat Cancer. 2016 Nov;23(11):R517-R525. doi: 10.1530/ERC-16-0334. Epub 2016 Sep 12.
A variety of studies have suggested that epithelial to mesenchymal transition (EMT) may be important in the progression of cancer in patients through metastasis and/or therapeutic resistance. A number of pathways have been investigated in EMT in cancer cells. Recently, changes in plasma membrane ion channel expression as a consequence of EMT have been reported. Other studies have identified specific ion channels able to regulate aspects of EMT induction. The utility of plasma membrane ion channels as targets for pharmacological modulation make them attractive for therapeutic approaches to target EMT. In this review, we provide an overview of some of the key plasma membrane ion channel types and highlight some of the studies that are beginning to define changes in plasma membrane ion channels as a consequence of EMT and also their possible roles in EMT induction.
多项研究表明，上皮-间质转化（EMT）可能在癌症患者的病情进展中发挥重要作用，其通过转移和/或治疗抵抗来实现。人们已经对癌细胞中EMT的多种途径进行了研究。最近，有报道称EMT会导致质膜离子通道表达发生变化。其他研究也已确定了能够调节EMT诱导相关方面的特定离子通道。质膜离子通道作为药理学调节的靶点，这使其在针对EMT的治疗方法中颇具吸引力。在本综述中，我们概述了一些关键的质膜离子通道类型，并着重介绍了一些研究，这些研究开始明确EMT导致的质膜离子通道变化及其在EMT诱导中可能发挥的作用。
