Bartoszewska Elżbieta, Czapla Melania, Rakoczy Katarzyna, Filipski Michał, Rekiel Katarzyna, Skowron Izabela, Kulbacka Julita, Kobierzycki Christopher
Faculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 5, 50-345 Wroclaw, Poland.
Student Research Group No. K148, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland.
Cancers (Basel). 2025 May 1;17(9):1538. doi: 10.3390/cancers17091538.
Ion channels are proteins that regulate the flow of ions across cell membranes, playing a vital role in cervical cancer development and progression. These channels serve as both potential diagnostic markers and therapeutic targets, offering new opportunities for cancer treatment. Moreover, ion channels are crucial molecular indicators and possible therapeutic targets due to their role in the development of cervical cancer. Our review focuses on the various types of ion channels which are associated with cervical cancer (CCa), including sodium, calcium, and potassium channels. In our review, we clarify their diagnostic and prognostic value, as well as their relationship to the prognosis and stage of the disease. We also examine how ion channels contribute to the metastasis of cervical cancer, specifically in relation to their influence on cell motility, invasion, and interaction with the tumor microenvironment. By examining preclinical and clinical research involving ion channel blockers and modulators, we also highlight the therapeutic potential of targeting ion channels. We have demonstrated the available assays and imaging methods based on ion channel activity as examples of emerging diagnostic breakthroughs that show promise for enhancing the early detection of cervical cancer. Additionally, the possibility that ion channel modulator-based combination therapy could improve the efficacy of traditional treatments is investigated. To demonstrate the potential of ion channels in cervical cancer diagnosis and treatment, our review highlights the current challenges and the promising role in cervical cancer diagnostics and therapy.
离子通道是调节离子跨细胞膜流动的蛋白质，在宫颈癌的发生和发展中起着至关重要的作用。这些通道既是潜在的诊断标志物，也是治疗靶点，为癌症治疗提供了新的机会。此外，由于离子通道在宫颈癌发生中的作用，它们是关键的分子指标和可能的治疗靶点。我们的综述重点关注与宫颈癌（CCa）相关的各种类型的离子通道，包括钠通道、钙通道和钾通道。在我们的综述中，我们阐明了它们的诊断和预后价值，以及它们与疾病预后和分期的关系。我们还研究了离子通道如何促进宫颈癌的转移，特别是它们对细胞运动、侵袭以及与肿瘤微环境相互作用的影响。通过研究涉及离子通道阻滞剂和调节剂的临床前和临床研究，我们还强调了靶向离子通道的治疗潜力。我们展示了基于离子通道活性的现有检测方法和成像方法，作为新兴诊断突破的例子，这些突破有望提高宫颈癌的早期检测。此外，还研究了基于离子通道调节剂的联合治疗能否提高传统治疗疗效的可能性。为了证明离子通道在宫颈癌诊断和治疗中的潜力，我们的综述强调了当前的挑战以及在宫颈癌诊断和治疗中所起的有前景的作用。
