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1
Heart rate reduction may be a major determinant of vascular tone in esmolol-treated septic shock patients-although still remains to be confirmed!心率降低可能是艾司洛尔治疗的感染性休克患者血管张力的主要决定因素——尽管仍有待证实！
J Thorac Dis. 2016 Aug;8(8):E829-32. doi: 10.21037/jtd.2016.07.66.
2
Heart rate reduction with esmolol is associated with improved arterial elastance in patients with septic shock: a prospective observational study.艾司洛尔降低心率与感染性休克患者动脉弹性改善相关：一项前瞻性观察研究。
Intensive Care Med. 2016 Oct;42(10):1528-1534. doi: 10.1007/s00134-016-4351-2. Epub 2016 Apr 21.
3
Effects of low doses of esmolol on cardiac and vascular function in experimental septic shock.小剂量艾司洛尔对实验性脓毒性休克心脏和血管功能的影响。
Crit Care. 2016 Dec 21;20(1):407. doi: 10.1186/s13054-016-1580-2.
4
Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial.艾司洛尔对感染性休克患者血流动力学和临床结局的影响：一项随机临床试验。
JAMA. 2013 Oct 23;310(16):1683-91. doi: 10.1001/jama.2013.278477.
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[Effect of esmolol in septic shock patients with tachycardia: a randomized clinical trial].艾司洛尔对脓毒性休克心动过速患者的影响：一项随机临床试验
Zhonghua Yi Xue Za Zhi. 2019 May 7;99(17):1317-1322. doi: 10.3760/cma.j.issn.0376-2491.2019.17.009.
6
[Esmolol improves clinical outcome and tissue oxygen metabolism in patients with septic shock through controlling heart rate].艾司洛尔通过控制心率改善感染性休克患者的临床结局和组织氧代谢
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Sep;27(9):759-63.
7
[Effect of esmolol on fluid responsiveness and hemodynamic parameters in patients with septic shock].艾司洛尔对感染性休克患者液体反应性及血流动力学参数的影响
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Nov;27(11):885-9.
8
[Effect of esmolol on hemodynamics and clinical outcomes in patients with septic shock].艾司洛尔对感染性休克患者血流动力学及临床结局的影响
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017 May;29(5):390-395. doi: 10.3760/cma.j.issn.2095-4352.2017.05.002.
9
The influence of esmolol on septic shock and sepsis: A meta-analysis of randomized controlled studies.艾司洛尔对脓毒性休克和脓毒症的影响：一项随机对照研究的荟萃分析。
Am J Emerg Med. 2018 Mar;36(3):470-474. doi: 10.1016/j.ajem.2017.11.013. Epub 2017 Nov 8.
10
Microvascular effects of heart rate control with esmolol in patients with septic shock: a pilot study.脓毒性休克患者应用艾司洛尔控制心率的微血管效应：一项初步研究。
Crit Care Med. 2013 Sep;41(9):2162-8. doi: 10.1097/CCM.0b013e31828a678d.

引用本文的文献

1
Esmolol in septic shock: old pathophysiological concepts, an old drug, perhaps a new hemodynamic strategy in the right patient.艾司洛尔用于感染性休克：旧的病理生理学概念、一种老药，或许对合适的患者是一种新的血流动力学策略。
J Thorac Dis. 2016 Nov;8(11):3059-3062. doi: 10.21037/jtd.2016.11.111.

本文引用的文献

1
β1-Adrenergic Inhibition Improves Cardiac and Vascular Function in Experimental Septic Shock.β1-肾上腺素能抑制改善实验性脓毒性休克的心功能和血管功能。
Crit Care Med. 2015 Sep;43(9):e332-40. doi: 10.1097/CCM.0000000000001078.
2
Systemic inflammatory response syndrome criteria in defining severe sepsis.全身性炎症反应综合征标准在严重脓毒症中的应用。
N Engl J Med. 2015 Apr 23;372(17):1629-38. doi: 10.1056/NEJMoa1415236. Epub 2015 Mar 17.
3
Goal-directed resuscitation for patients with early septic shock.目标导向性复苏治疗早期感染性休克患者。
N Engl J Med. 2014 Oct 16;371(16):1496-506. doi: 10.1056/NEJMoa1404380. Epub 2014 Oct 1.
4
Ventriculoarterial decoupling in human septic shock.人类感染性休克中的心室动脉解耦联
Crit Care. 2014 Apr 24;18(2):R80. doi: 10.1186/cc13842.
5
A randomized trial of protocol-based care for early septic shock.一项基于方案的早期脓毒性休克护理的随机试验。
N Engl J Med. 2014 May 1;370(18):1683-93. doi: 10.1056/NEJMoa1401602. Epub 2014 Mar 18.
6
Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial.艾司洛尔对感染性休克患者血流动力学和临床结局的影响：一项随机临床试验。
JAMA. 2013 Oct 23;310(16):1683-91. doi: 10.1001/jama.2013.278477.
7
The epidemiology of septic shock in French intensive care units: the prospective multicenter cohort EPISS study.法国重症监护病房感染性休克的流行病学：前瞻性多中心队列EPISS研究
Crit Care. 2013 Apr 25;17(2):R65. doi: 10.1186/cc12598.
8
Beta-1 blocker improves survival of septic rats through preservation of gut barrier function.β-1 受体阻滞剂通过维持肠道屏障功能改善脓毒症大鼠的存活率。
Intensive Care Med. 2011 Nov;37(11):1849-56. doi: 10.1007/s00134-011-2326-x. Epub 2011 Aug 17.
9
Peripheral vascular decoupling in porcine endotoxic shock.猪内毒素性休克中的周围血管去耦联。
J Appl Physiol (1985). 2011 Sep;111(3):853-60. doi: 10.1152/japplphysiol.00066.2011. Epub 2011 Jun 23.
10
Cardioprotection, attenuated systemic inflammation, and survival benefit of beta1-adrenoceptor blockade in severe sepsis in rats.β1-肾上腺素能受体阻滞剂在大鼠严重脓毒症中的心肌保护、减轻全身炎症和生存获益。
Crit Care Med. 2010 Feb;38(2):388-94. doi: 10.1097/CCM.0b013e3181c03dfa.

Heart rate reduction may be a major determinant of vascular tone in esmolol-treated septic shock patients-although still remains to be confirmed!

作者信息

Kimmoun Antoine, Wei Chaoije, Levy Bruno, Annane Djillali

机构信息

Medical Intensive Care Unit and Medico-surgical Cardiology Department, CHU Brabois 54500 Vandoeuvre les Nancy, France;; Shock Group, INSERM U1116, Faculté de Médecine, 54500 Vandoeuvre les Nancy, France;; Lorraine University, 34 Cours Léopold, Nancy, France;

Shock Group, INSERM U1116, Faculté de Médecine, 54500 Vandoeuvre les Nancy, France;; Lorraine University, 34 Cours Léopold, Nancy, France;

出版信息

J Thorac Dis. 2016 Aug;8(8):E829-32. doi: 10.21037/jtd.2016.07.66.

DOI:10.21037/jtd.2016.07.66
PMID:27619799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4999694/
Abstract
摘要