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Esmolol in septic shock: old pathophysiological concepts, an old drug, perhaps a new hemodynamic strategy in the right patient.

作者信息

Morelli Andrea, Sanfilippo Filippo, Romano Salvatore Mario

机构信息

Department of Cardiovascular, Respiratory, Nephrological, Anesthesiological and Geriatric Sciences, University of Rome, "La Sapienza", Policlinico Umberto Primo, Rome, Italy.

Department of Anesthesia and Intensive Care, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), Palermo, Italy.

出版信息

J Thorac Dis. 2016 Nov;8(11):3059-3062. doi: 10.21037/jtd.2016.11.111.

DOI:10.21037/jtd.2016.11.111
PMID:28066583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5179389/
Abstract
摘要

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J Thorac Dis. 2016 Nov;8(11):3059-3062. doi: 10.21037/jtd.2016.11.111.
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Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial.艾司洛尔对感染性休克患者血流动力学和临床结局的影响：一项随机临床试验。
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Sep;27(9):759-63.
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本文引用的文献

1
Ventriculo-arterial coupling: the comeback?心室-动脉耦合：卷土重来？
J Thorac Dis. 2016 Sep;8(9):2287-2289. doi: 10.21037/jtd.2016.08.34.
2
Heart rate reduction may be a major determinant of vascular tone in esmolol-treated septic shock patients-although still remains to be confirmed!心率降低可能是艾司洛尔治疗的感染性休克患者血管张力的主要决定因素——尽管仍有待证实！
J Thorac Dis. 2016 Aug;8(8):E829-32. doi: 10.21037/jtd.2016.07.66.
3
Beta-blockers in septic shock: a magnifying glass on the relation heart vessel.
J Thorac Dis. 2016 Aug;8(8):E802-4. doi: 10.21037/jtd.2016.07.12.
4
Heart rate reduction with esmolol is associated with improved arterial elastance in patients with septic shock: a prospective observational study.艾司洛尔降低心率与感染性休克患者动脉弹性改善相关：一项前瞻性观察研究。
Intensive Care Med. 2016 Oct;42(10):1528-1534. doi: 10.1007/s00134-016-4351-2. Epub 2016 Apr 21.
5
Sequential N-Terminal Pro-B-Type Natriuretic Peptide and High-Sensitivity Cardiac Troponin Measurements During Albumin Replacement in Patients With Severe Sepsis or Septic Shock.严重脓毒症或脓毒性休克患者白蛋白替代治疗期间连续测定 N 末端脑利钠肽前体 B 型和高敏心肌肌钙蛋白
Crit Care Med. 2016 Apr;44(4):707-16. doi: 10.1097/CCM.0000000000001473.
6
Timing and causes of death in septic shock.感染性休克的发生时间和死亡原因。
Ann Intensive Care. 2015 Dec;5(1):16. doi: 10.1186/s13613-015-0058-8. Epub 2015 Jun 20.
7
Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial.艾司洛尔对感染性休克患者血流动力学和临床结局的影响：一项随机临床试验。
JAMA. 2013 Oct 23;310(16):1683-91. doi: 10.1001/jama.2013.278477.
8
Central venous pressure and shock index predict lack of hemodynamic response to volume expansion in septic shock: a prospective, observational study.中心静脉压和休克指数预测感染性休克患者对容量复苏无血液动力学反应：一项前瞻性观察研究。
J Crit Care. 2012 Dec;27(6):609-15. doi: 10.1016/j.jcrc.2012.07.021. Epub 2012 Oct 17.
9
Sympathetic overstimulation during critical illness: adverse effects of adrenergic stress.危重病期间的交感神经过度刺激：肾上腺素能应激的不良效应。
J Intensive Care Med. 2009 Sep-Oct;24(5):293-316. doi: 10.1177/0885066609340519. Epub 2009 Aug 23.
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Landiolol, an ultrashort-acting beta1-adrenoceptor antagonist, has protective effects in an LPS-induced systemic inflammation model.兰地洛尔是一种超短效β1肾上腺素能受体拮抗剂，在脂多糖诱导的全身炎症模型中具有保护作用。
Shock. 2009 May;31(5):515-20. doi: 10.1097/SHK.0b013e3181863689.