Li Zheng, Shen Jianxiong, Chan Matthew T V, Wu William Ka Kei
Department of Orthopedics Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.
J Cell Mol Med. 2017 Jan;21(1):177-184. doi: 10.1111/jcmm.12951. Epub 2016 Sep 13.
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy with poor prognosis. Despite improvements in its diagnosis and therapy, the prognosis for ICC patients remains poor. An improved understanding of ICC pathogenesis and consequential identification of novel therapeutic targets would improve the prognosis of ICC patients. MicroRNAs (miRNAs) are a class of highly conserved, endogenous, small non-coding RNA molecules of 18-23 nucleotides in length, which regulate gene expression through complementary base-pairing with target messenger RNAs and subsequent gene silencing. Several studies have shown deregulated expression of miRNAs in ICC cell lines and tissues, in which these miRNAs play important roles in ICC apoptosis, cell proliferation, invasion, migration and metastasis. In this review, we illustrate the potential role of miRNA in the pathogenesis of ICC and explore the possibilities of using miRNAs as prognostic and diagnostic markers, as well as therapeutic targets in ICC.
肝内胆管癌（ICC）是第二常见的原发性肝脏恶性肿瘤，预后较差。尽管其诊断和治疗有所改善，但ICC患者的预后仍然很差。对ICC发病机制的深入了解以及随之而来的新型治疗靶点的识别将改善ICC患者的预后。微小RNA（miRNA）是一类高度保守的内源性小非编码RNA分子，长度为18 - 23个核苷酸，它们通过与靶信使RNA的互补碱基配对和随后的基因沉默来调节基因表达。多项研究表明，miRNA在ICC细胞系和组织中的表达失调，这些miRNA在ICC细胞凋亡、增殖、侵袭、迁移和转移中发挥重要作用。在本综述中，我们阐述了miRNA在ICC发病机制中的潜在作用，并探讨了将miRNA用作ICC预后和诊断标志物以及治疗靶点的可能性。
