miRNA-mRNA 表达整合分析探索其在肝内胆管癌中的潜在作用。

Integration analysis of miRNA-mRNA expression exploring their potential roles in intrahepatic cholangiocarcinoma.

机构信息

Department of Blood Transfusion, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, People's Republic of China.

Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.

出版信息

Sci Rep. 2023 May 24;13(1):8362. doi: 10.1038/s41598-023-35288-0.

DOI:10.1038/s41598-023-35288-0

PMID:37225858

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10209200/

Abstract

Intrahepatic cholangiocarcinoma (ICC) is the second common primary hepatic malignancy tumor. In this study, an integrative analysis of differentially expressed genes (DEGs) and miRNAs from the ICC onset and adjacent normal tissues were performed to explore the regulatory roles of miRNA-mRNA interaction. A total of 1018 DEGs and 39 miRNAs were likely involved in ICC pathogenesis, suggesting the changes in cell metabolism in ICC development. The built network indicated that 30 DEGs were regulated by 16 differentially expressed miRNA. The screened DEGs and miRNA together were probably considered the biomarkers of ICC, and their important roles in ICC pathogenesis remain to be elucidated. This study could provide a good basis to uncover the regulatory mechanism of miRNA and mRNAs in ICC pathogenesis.

摘要

肝内胆管癌（ICC）是第二常见的原发性肝脏恶性肿瘤。本研究通过整合 ICC 发病和相邻正常组织中的差异表达基因（DEGs）和 miRNA 的分析，探讨 miRNA-mRNA 相互作用的调控作用。共有 1018 个 DEGs 和 39 个 miRNA 可能参与 ICC 的发病机制，提示 ICC 发展过程中细胞代谢的变化。构建的网络表明，30 个 DEGs 受 16 个差异表达 miRNA 的调控。筛选出的 DEGs 和 miRNA 可能共同作为 ICC 的生物标志物，其在 ICC 发病机制中的重要作用仍有待阐明。本研究可为揭示 miRNA 和 mRNAs 在 ICC 发病机制中的调控机制提供良好的基础。