Meurman J H, Jousimies-Somer H, Suomala P, Alaluusua S, Torkko H, Asikainen S
Oral Microbiol Immunol. 1989 Jun;4(2):117-9. doi: 10.1111/j.1399-302x.1989.tb00109.x.
The in vitro susceptibility of 128 bacterial strains was tested to amine fluoride-stannous fluoride (AmF + SnF) and chlorhexidine (CHX) solutions. Actinobacillus actinomycetemcomitans, Streptococcus mutans, and Bacteroides intermedius were among the species investigated. The 50% and 90% minimal inhibitory concentrations (MICs) were assessed by an agar dilution method. The MIC ranges for A. actinomycetemcomitans were 2-32 micrograms/ml for CHX and 0.25-64 micrograms/ml for AmF + SnF. The respective values for S. mutans were 0.5-8 micrograms/ml (CHX) and 2-8 micrograms/ml (AmF + SnF); and 4-8 micrograms/ml (CHX) and 2-4 micrograms/ml (AmF + SnF) for B. intermedius. Streptococcus faecalis and Staphylococcus aureus were most resistant of the control strains (MIC 64 micrograms/ml to CHX and 32 micrograms/ml to AmF + SnF, respectively). Thus, both solutions tested exerted a definite inhibitory action on the dental plaque pathogens studied.
对128株细菌进行了体外药敏试验，检测其对胺氟-氟化亚锡（AmF + SnF）和洗必泰（CHX）溶液的敏感性。研究的菌种包括伴放线放线杆菌、变形链球菌和中间普氏菌。采用琼脂稀释法评估50%和90%最小抑菌浓度（MIC）。伴放线放线杆菌对CHX的MIC范围为2 - 32微克/毫升，对AmF + SnF为0.25 - 64微克/毫升。变形链球菌的相应值分别为0.5 - 8微克/毫升（CHX）和2 - 8微克/毫升（AmF + SnF）；中间普氏菌为4 - 8微克/毫升（CHX）和2 - 4微克/毫升（AmF + SnF）。粪肠球菌和金黄色葡萄球菌是对照菌株中耐药性最强的（对CHX的MIC分别为64微克/毫升，对AmF + SnF为32微克/毫升）。因此，所测试的两种溶液对所研究的牙菌斑病原体均有明确的抑制作用。
