Ostela I, Tenovuo J
Department of Cariology, University of Turku, Finland.
Scand J Dent Res. 1990 Feb;98(1):1-7. doi: 10.1111/j.1600-0722.1990.tb00933.x.
The in vitro susceptibility of Streptococcus mutans, S. sobrinus and Lactobacillus casei to dental gels containing various combinations of amine fluoride (AmF 297), stannous fluoride (SnF2), and chlorhexidine (CHX) was studied. The combination of AmF-SnF2 with a total fluoride content of 1.2% was the most effective against mutans streptococci but not against L. casei. At notably lower total fluoride concentration (0.4%), AmF as such or combined with SnF2, was significantly less effective against mutans streptococci than CHX or CHX-AmF-SnF2 combinations. CHX-AmF combination was a slightly more potent inhibitor of streptococcal growth than CHX-NaF. With L. casei the differences between various gels were small but CHX alone seemed to be the most effective. Of the studied agents, CHX seemed to be the most potent individual chemotherapeutic compound whose activity against S. mutans could be enhanced by combining it with AmF. However, clinical experiments are required to test the in vivo antibacterial efficacy of CHX-AmF and AmF-SnF2 combinations which were most effective in our in vitro experiments.
研究了变形链球菌、远缘链球菌和干酪乳杆菌对含有不同组合的胺氟（AmF 297）、氟化亚锡（SnF2）和洗必泰（CHX）的牙科凝胶的体外敏感性。总氟含量为1.2%的AmF-SnF2组合对变形链球菌最有效，但对干酪乳杆菌无效。在显著较低的总氟浓度（0.4%）下，单独的AmF或与SnF2组合对变形链球菌的效果明显不如CHX或CHX-AmF-SnF2组合。CHX-AmF组合对链球菌生长的抑制作用略强于CHX-NaF。对于干酪乳杆菌，各种凝胶之间的差异较小，但单独的CHX似乎最有效。在所研究的药剂中，CHX似乎是最有效的单一化疗化合物，将其与AmF组合可增强其对变形链球菌的活性。然而，需要进行临床试验来测试CHX-AmF和AmF-SnF2组合在我们体外实验中最有效的体内抗菌效果。
