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[明天和后天进行结石治疗]

[Stone treatment tomorrow and the day after].

作者信息

Miernik A, Hein S, Adams F, Halbritter J, Schoenthaler M

机构信息

Klinik für Urologie, Universitätsklinik Freiburg, Hugstetterstr. 55, 79106, Freiburg, Deutschland.

Max Planck-Institut für Intelligente Systeme, Stuttgart, Deutschland.

出版信息

Urologe A. 2016 Oct;55(10):1309-1316. doi: 10.1007/s00120-016-0227-x.

DOI:10.1007/s00120-016-0227-x
PMID:27620184
Abstract

Urological and surgical treatment of urinary stones are highly technological and technology-driven disciplines in present-day surgery. German medical engineering has always been recognized for its technical innovations in endoscopic surgery. Current and future trends are indicative of further miniaturization and automation of surgical instruments and assist systems to facilitate endourological procedures as well as improvements in the quality of results and ergonomics. These technologies include, e. g. 3D-tracking to facilitate access to the pelvicaliceal system for percutaneous nephrolithotomy (PNL) or robotic master-slave systems for endourology. The aim of all future stone treatment should be complete stone removal. This could be achieved by improved stone fragmentation ("micron-sized debris") or complete removal of fragments (e. g. using a "stone glue"). Integration of diagnostic procedures and treatments will constitute a key aspect of future developments in medical engineering. Intelligent laser systems may be capable of distinguishing stones from mucosa and artificial surfaces and may be used for immediate stone analysis during surgery. A simpler and faster availability of metabolic ("metabolomics") and genetic ("genomics") diagnostics will help to facilitate and improve individual metaphylaxis, e. g. in patient self-management. Nanotechnology and microrobots that may be used for endoluminal diagnostics and treatment of the urinary tract are already in development.

摘要

在当今外科手术中,泌尿系统结石的泌尿外科治疗和外科治疗是技术高度密集且由技术驱动的学科。德国医学工程一直以其在内镜手术方面的技术创新而闻名。当前和未来的趋势表明,手术器械和辅助系统将进一步小型化和自动化,以促进腔内泌尿外科手术,并提高手术效果质量和人体工程学性能。这些技术包括,例如用于经皮肾镜取石术(PNL)时便于进入肾盂肾盏系统的三维跟踪技术,或用于腔内泌尿外科的机器人主从系统。未来所有结石治疗的目标都应该是完全清除结石。这可以通过改进结石破碎(“微米级碎片”)或完全清除碎片(例如使用“结石胶水”)来实现。诊断程序和治疗的整合将成为医学工程未来发展的一个关键方面。智能激光系统或许能够区分结石与黏膜及人造表面,并可用于手术期间的即时结石分析。代谢(“代谢组学”)和基因(“基因组学”)诊断更简便、更快速地可得,将有助于促进和改善个体预防措施,例如在患者自我管理方面。可用于腔内诊断和治疗尿路的纳米技术和微型机器人已经在研发中。

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[Stone treatment tomorrow and the day after].[明天和后天进行结石治疗]
Urologe A. 2016 Oct;55(10):1309-1316. doi: 10.1007/s00120-016-0227-x.
2
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[Individualized evidence-based interventional stone treatment : One stone, many question marks?].[个体化循证介入性结石治疗:一块结石,诸多问号?]
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EAU Guidelines on Interventional Treatment for Urolithiasis.EAU 指南:尿石症的介入治疗
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本文引用的文献

1
Novel Biocompatible Adhesive for Intrarenal Embedding and Endoscopic Removal of Small Residual Fragments after Minimally Invasive Stone Treatment in an Ex Vivo Porcine Kidney Model: Initial Evaluation of a Prototype.新型生物相容性黏合剂在微创结石治疗后肾内嵌入和内镜取出小残余碎片的应用:在离体猪肾模型中的初步评价。
J Urol. 2016 Dec;196(6):1772-1777. doi: 10.1016/j.juro.2016.05.094. Epub 2016 May 30.
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Quality Assessment of Urinary Stone Analysis: Results of a Multicenter Study of Laboratories in Europe.尿石分析的质量评估:欧洲实验室多中心研究结果
PLoS One. 2016 Jun 1;11(6):e0156606. doi: 10.1371/journal.pone.0156606. eCollection 2016.
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Mutations in SLC26A1 Cause Nephrolithiasis.
SLC26A1基因的突变导致肾结石。
Am J Hum Genet. 2016 Jun 2;98(6):1228-1234. doi: 10.1016/j.ajhg.2016.03.026. Epub 2016 May 19.
4
Endoscopically Determined Stone Clearance Predicts Disease Recurrence Within 5 Years After Retrograde Intrarenal Surgery.内镜确定的结石清除情况可预测逆行性肾内手术后5年内的疾病复发。
J Endourol. 2016 Jun;30(6):644-9. doi: 10.1089/end.2016.0101. Epub 2016 Apr 22.
5
Prevalence of Monogenic Causes in Pediatric Patients with Nephrolithiasis or Nephrocalcinosis.小儿肾结石或肾钙质沉着症患者单基因病因的患病率。
Clin J Am Soc Nephrol. 2016 Apr 7;11(4):664-72. doi: 10.2215/CJN.07540715. Epub 2016 Jan 19.
6
Clinical significance of residual fragments in 2015: impact, detection, and how to avoid them.2015年残留碎片的临床意义:影响、检测及如何避免残留碎片
World J Urol. 2016 Jun;34(6):771-8. doi: 10.1007/s00345-015-1713-2. Epub 2015 Oct 23.
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Is in vivo analysis of urinary stone composition feasible? Evaluation of an experimental setup of a Raman system coupled to commercial lithotripsy laser fibers.对尿结石成分进行体内分析是否可行?对耦合到商用碎石激光纤维的拉曼系统实验装置的评估。
World J Urol. 2015 Oct;33(10):1593-9. doi: 10.1007/s00345-014-1477-0. Epub 2015 Jan 4.
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Taking advantage of hyperspectral imaging classification of urinary stones against conventional infrared spectroscopy.利用高光谱成像对尿结石进行分类,以对抗传统红外光谱法。
J Biomed Opt. 2014 Dec;19(12):126004. doi: 10.1117/1.JBO.19.12.126004.
9
Impact of pulse duration on Ho:YAG laser lithotripsy: fragmentation and dusting performance.脉冲持续时间对钬激光碎石术的影响:碎石及粉末化性能
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10
Fourteen monogenic genes account for 15% of nephrolithiasis/nephrocalcinosis.14个单基因导致15%的肾结石/肾钙质沉着症。
J Am Soc Nephrol. 2015 Mar;26(3):543-51. doi: 10.1681/ASN.2014040388. Epub 2014 Oct 8.