Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Sci Rep. 2016 Sep 13;6:33069. doi: 10.1038/srep33069.
The patients of liver cirrhosis associated with portal vein thrombosis (PVT) can be effectively treated by transjugular intrahepatic portosystemic stent shunt (TIPS). Although the corresponding TIPS procedures have already performed on the patients to different types of PVT, the procedures are not specific and the relationship between different types of PVT and technical success rate of TIPS is unclear. What's more, we aimed to explore the relationship between survival and vascular patency immediately after TIPS. 191 subjects underwent retrospective assessment. Appropriate TIPS procedures were performed based on our more specific classification. The overall success rate of TIPS was 95.8% (183/191). Success rate was significantly different between Grade II and Grade IV thrombosis (χ(2) = 5.294, P = 0.021). The 1-, 2-, 3-, 4-and 5-year survival rates were 95.6%, 89.1%, 83.1%, 76.5% and 67.8%, respectively. The overall survival time of completely patent PV and incomplete patent PV immediately after TIPS was 57.05 ± 0.75 vs. 39.12 ± 2.64 months, respectively (P < 0.0001). We conclude that appropriate TIPS procedures and lower grade of PVT are essential for better technical success rate of TIPS. The patency of target vessels is important for survival.
肝硬化伴门静脉血栓形成（PVT）的患者可以通过经颈静脉肝内门体分流术（TIPS）进行有效治疗。虽然已经对不同类型的 PVT 患者进行了相应的 TIPS 手术，但这些手术并不具体，不同类型的 PVT 与 TIPS 技术成功率之间的关系尚不清楚。此外，我们旨在探讨 TIPS 后即刻生存与血管通畅性之间的关系。对 191 例患者进行回顾性评估。根据我们更具体的分类，对患者进行适当的 TIPS 手术。TIPS 的总体成功率为 95.8%（183/191）。血栓形成程度为 II 级和 IV 级时，成功率有显著差异（χ(2) = 5.294，P = 0.021）。1、2、3、4 和 5 年的生存率分别为 95.6%、89.1%、83.1%、76.5%和 67.8%。TIPS 后即刻完全通畅和不完全通畅 PV 的总生存时间分别为 57.05±0.75 个月和 39.12±2.64 个月（P < 0.0001）。我们得出结论，适当的 TIPS 手术和较低等级的 PVT 是提高 TIPS 技术成功率的关键。靶血管通畅性对生存至关重要。
