Improved survival in critically ill patients: are large RCTs more useful than personalized medicine? We are not sure.

作者信息

Gattinoni Luciano, Tonetti Tommaso, Quintel Michael

机构信息

Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany.

Department of Medicine, Institute of Anesthesiology and Intensive Care Medicine, University of Padova, Padova, Italy.

出版信息

Intensive Care Med. 2016 Nov;42(11):1781-1783. doi: 10.1007/s00134-016-4471-8. Epub 2016 Sep 12.

DOI:10.1007/s00134-016-4471-8

PMID:27620284

Abstract

摘要

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Lung Recruitment Assessed by Respiratory Mechanics and Computed Tomography in Patients with Acute Respiratory Distress Syndrome. What Is the Relationship?

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Personalized Medicine for Sepsis.

Am J Med Sci. 2015 Nov;350(5):409-13. doi: 10.1097/MAJ.0000000000000558.

Acquiring knowledge in intensive care: merits and pitfalls of randomized controlled trials.

Intensive Care Med. 2015 Aug;41(8):1460-4. doi: 10.1007/s00134-015-3837-7. Epub 2015 Jun 3.

Phenotypic clusters within sepsis-associated multiple organ dysfunction syndrome.

Intensive Care Med. 2015 May;41(5):814-22. doi: 10.1007/s00134-015-3764-7. Epub 2015 Apr 8.

Trial of early, goal-directed resuscitation for septic shock.

N Engl J Med. 2015 Apr 2;372(14):1301-11. doi: 10.1056/NEJMoa1500896. Epub 2015 Mar 17.

Goal-directed resuscitation in septic shock.

N Engl J Med. 2015 Jan 8;372(2):190-1. doi: 10.1056/NEJMc1413936.

Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study.

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相似文献

Improved survival in critically ill patients: are large RCTs more useful than personalized medicine? We are not sure.

Intensive Care Med. 2016 Nov;42(11):1781-1783. doi: 10.1007/s00134-016-4471-8. Epub 2016 Sep 12.

Improved survival in critically ill patients: are large RCTs more useful than personalized medicine? No.

Intensive Care Med. 2016 Nov;42(11):1778-1780. doi: 10.1007/s00134-016-4482-5. Epub 2016 Sep 12.

Improved survival in critically ill patients: are large RCTs more useful than personalized medicine? Yes.

Intensive Care Med. 2016 Nov;42(11):1775-1777. doi: 10.1007/s00134-016-4491-4. Epub 2016 Sep 12.

Should blood transfusion be individualised? We are not sure.

Intensive Care Med. 2015 Nov;41(11):1980-2. doi: 10.1007/s00134-015-4034-4. Epub 2015 Sep 10.

Should red cell transfusion be individualized? Yes.

Intensive Care Med. 2015 Nov;41(11):1973-6. doi: 10.1007/s00134-015-3950-7. Epub 2015 Jul 7.

Evidence-based nutrition guidelines for critically ill adults.

JAMA. 2009 Apr 15;301(15):1543; author reply 1543-4. doi: 10.1001/jama.2009.493.

[Evidence-based pharmacological interventions in intensive therapy].

Ugeskr Laeger. 2009 Mar 2;171(10):805-8.

Precision medicine for all? Challenges and opportunities for a precision medicine approach to critical illness.

Crit Care. 2017 Oct 18;21(1):257. doi: 10.1186/s13054-017-1836-5.

Impact of the pulmonary artery catheter in critically ill patients: meta-analysis of randomized clinical trials.

JAMA. 2005 Oct 5;294(13):1664-70. doi: 10.1001/jama.294.13.1664.

Alterations of blood glucose homeostasis in critically ill children - hyperglycemia.

Pediatr Endocrinol Diabetes Metab. 2007;13(1):43-6.

引用本文的文献

Use of extracorporeal blood purification therapies in sepsis: the current paradigm, available evidence, and future perspectives.

Crit Care. 2024 Dec 25;28(1):432. doi: 10.1186/s13054-024-05220-7.

Mechanical Ventilation in Pediatric and Neonatal Patients.

Front Physiol. 2022 Mar 17;12:805620. doi: 10.3389/fphys.2021.805620. eCollection 2021.

Effect sizes in ongoing randomized controlled critical care trials.

Crit Care. 2017 Jun 5;21(1):132. doi: 10.1186/s13054-017-1726-x.

Evidence or belief-based medicine? Ten doubts.

Intensive Care Med. 2017 Sep;43(9):1392-1394. doi: 10.1007/s00134-017-4724-1. Epub 2017 Feb 24.

本文引用的文献

Lung Recruitment Assessed by Respiratory Mechanics and Computed Tomography in Patients with Acute Respiratory Distress Syndrome. What Is the Relationship?

Am J Respir Crit Care Med. 2016 Jun 1;193(11):1254-63. doi: 10.1164/rccm.201507-1413OC.

Personalized Medicine for Sepsis.

Am J Med Sci. 2015 Nov;350(5):409-13. doi: 10.1097/MAJ.0000000000000558.

Acquiring knowledge in intensive care: merits and pitfalls of randomized controlled trials.

Intensive Care Med. 2015 Aug;41(8):1460-4. doi: 10.1007/s00134-015-3837-7. Epub 2015 Jun 3.

Phenotypic clusters within sepsis-associated multiple organ dysfunction syndrome.

Intensive Care Med. 2015 May;41(5):814-22. doi: 10.1007/s00134-015-3764-7. Epub 2015 Apr 8.

Trial of early, goal-directed resuscitation for septic shock.

N Engl J Med. 2015 Apr 2;372(14):1301-11. doi: 10.1056/NEJMoa1500896. Epub 2015 Mar 17.

Goal-directed resuscitation in septic shock.

N Engl J Med. 2015 Jan 8;372(2):190-1. doi: 10.1056/NEJMc1413936.

Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study.

Lancet Respir Med. 2015 Jan;3(1):53-60. doi: 10.1016/S2213-2600(14)70290-5. Epub 2014 Dec 18.

Functional hemodynamic monitoring.

Crit Care Clin. 2015 Jan;31(1):89-111. doi: 10.1016/j.ccc.2014.08.005.

Genome-wide association study: a useful tool to identify common genetic variants associated with drug toxicity and efficacy in cancer pharmacogenomics.

Clin Cancer Res. 2014 May 15;20(10):2541-52. doi: 10.1158/1078-0432.CCR-13-2755.

A randomized trial of protocol-based care for early septic shock.

N Engl J Med. 2014 May 1;370(18):1683-93. doi: 10.1056/NEJMoa1401602. Epub 2014 Mar 18.