危重症患者生存率的提高：大型随机对照试验比个性化医疗更有用吗？并非如此。 - Suppr

Improved survival in critically ill patients: are large RCTs more useful than personalized medicine? No.

作者信息

Vincent Jean-Louis

机构信息

Department of Intensive Care, Erasme University Hospital, Unversité Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium.

出版信息

Intensive Care Med. 2016 Nov;42(11):1778-1780. doi: 10.1007/s00134-016-4482-5. Epub 2016 Sep 12.

DOI:10.1007/s00134-016-4482-5

PMID:27620286

Abstract

摘要

相似文献

Improved survival in critically ill patients: are large RCTs more useful than personalized medicine? No.危重症患者生存率的提高：大型随机对照试验比个性化医疗更有用吗？并非如此。

Intensive Care Med. 2016 Nov;42(11):1778-1780. doi: 10.1007/s00134-016-4482-5. Epub 2016 Sep 12.

Improved survival in critically ill patients: are large RCTs more useful than personalized medicine? We are not sure.

Intensive Care Med. 2016 Nov;42(11):1781-1783. doi: 10.1007/s00134-016-4471-8. Epub 2016 Sep 12.

Improved survival in critically ill patients: are large RCTs more useful than personalized medicine? Yes.危重症患者生存率的提高：大型随机对照试验是否比个性化医疗更有用？答案是肯定的。

Intensive Care Med. 2016 Nov;42(11):1775-1777. doi: 10.1007/s00134-016-4491-4. Epub 2016 Sep 12.

Should red cell transfusion be individualized? Yes.红细胞输注应该个体化吗？答案是肯定的。

Intensive Care Med. 2015 Nov;41(11):1973-6. doi: 10.1007/s00134-015-3950-7. Epub 2015 Jul 7.

Should blood transfusion be individualised? We are not sure.输血应该个体化吗？我们不确定。

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Evidence-based nutrition guidelines for critically ill adults.危重症成年患者的循证营养指南

JAMA. 2009 Apr 15;301(15):1543; author reply 1543-4. doi: 10.1001/jama.2009.493.

[Evidence-based pharmacological interventions in intensive therapy].

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Impact of the pulmonary artery catheter in critically ill patients: meta-analysis of randomized clinical trials.肺动脉导管对重症患者的影响：随机临床试验的荟萃分析

JAMA. 2005 Oct 5;294(13):1664-70. doi: 10.1001/jama.294.13.1664.

Alterations of blood glucose homeostasis in critically ill children - hyperglycemia.危重症患儿血糖稳态的改变——高血糖症

Pediatr Endocrinol Diabetes Metab. 2007;13(1):43-6.

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Severity of hypoxemia may explain indeterminate results in pediatric trials of inhaled nitric oxide.低氧血症的严重程度可能解释了吸入一氧化氮儿科试验中不确定的结果。

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本文引用的文献

Saline versus balanced solutions: are clinical trials comparing two crystalloid solutions really needed?生理盐水与平衡液：真的需要进行比较两种晶体溶液的临床试验吗？

Crit Care. 2016 Aug 11;20(1):250. doi: 10.1186/s13054-016-1435-x.

Early goal-directed therapy: do we have a definitive answer?早期目标导向治疗：我们有明确的答案了吗？

Intensive Care Med. 2016 Jun;42(6):1048-50. doi: 10.1007/s00134-016-4295-6. Epub 2016 Mar 7.

Individual gene expression and personalised medicine in sepsis.脓毒症中的个体基因表达与个性化医疗

Lancet Respir Med. 2016 Apr;4(4):242-3. doi: 10.1016/S2213-2600(16)00068-0. Epub 2016 Feb 24.

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study.败血症患者个体宿主反应和结局的基因组图谱：一项前瞻性队列研究。

Lancet Respir Med. 2016 Apr;4(4):259-71. doi: 10.1016/S2213-2600(16)00046-1. Epub 2016 Feb 23.

Safety considerations of septic shock treatment.

Expert Opin Drug Saf. 2016;15(2):215-21. doi: 10.1517/14740338.2016.1128411. Epub 2015 Dec 30.

Developing a clinically feasible personalized medicine approach to pediatric septic shock.开发一种针对儿童脓毒性休克的临床可行的个性化医疗方法。

Am J Respir Crit Care Med. 2015 Feb 1;191(3):309-15. doi: 10.1164/rccm.201410-1864OC.

High versus low blood-pressure target in patients with septic shock.严重脓毒症及脓毒性休克患者的血压目标：高与低之比较

N Engl J Med. 2014 Apr 24;370(17):1583-93. doi: 10.1056/NEJMoa1312173. Epub 2014 Mar 18.

Prone positioning in severe acute respiratory distress syndrome.俯卧位通气治疗严重急性呼吸窘迫综合征。

N Engl J Med. 2013 Jun 6;368(23):2159-68. doi: 10.1056/NEJMoa1214103. Epub 2013 May 20.

A trial of intracranial-pressure monitoring in traumatic brain injury.颅脑创伤患者颅内压监测的临床试验。

N Engl J Med. 2012 Dec 27;367(26):2471-81. doi: 10.1056/NEJMoa1207363. Epub 2012 Dec 12.

Drotrecogin alfa (activated) in adults with septic shock.活化的人重组凝血因子 VII 治疗成人感染性休克。

N Engl J Med. 2012 May 31;366(22):2055-64. doi: 10.1056/NEJMoa1202290. Epub 2012 May 22.

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Improved survival in critically ill patients: are large RCTs more useful than personalized medicine? No.

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