注意缺陷多动障碍青少年血流动力学反应试验中的振幅变异性：前默认模式网络的作用及纹状体的非特异性作用。
Amplitude variability over trials in hemodynamic responses in adolescents with ADHD: The role of the anterior default mode network and the non-specific role of the striatum.
作者信息
Sørensen L, Eichele T, van Wageningen H, Plessen K J, Stevens M C
机构信息
Department of Biological and Medical Psychology, University of Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway; K. G. Jebsen Centre for Neuropsychiatric Disorders, Bergen, Norway.
Department of Biological and Medical Psychology, University of Bergen, Norway; K. G. Jebsen Centre for Neuropsychiatric Disorders, Bergen, Norway; Section for Clinical Neurophysiology, Department of Neurology, Haukeland University Hospital, Norway; The MIND Research Network, Albuquerque, NM, United States.
出版信息
Neuroimage Clin. 2016 Aug 8;12:397-404. doi: 10.1016/j.nicl.2016.08.007. eCollection 2016.
It has been suggested that intra-individual variability (IIV) in performance on attention and other cognitive tasks might be a cognitive endophenotype in individuals with ADHD. Despite robust IIV findings in behavioral data, only sparse data exist on how what type of brain dysfunction underlies variable response times. In this study, we asked whether ADHD IIV in reaction time on a commonly-used test of attention might be related to variation in hemodynamic responses (HRs) observed trial-to-trial. Based on previous studies linking IIV to regions within the "default mode" network (DMN), we predicted that adolescents with ADHD would have higher HR variability in the DMN compared with controls, and this in turn would be related to behavioral IIV. We also explored the influence of social anxiety on HR variability in ADHD as means to test whether higher arousal associated with high trait anxiety would affect the neural abnormalities. We assessed single-trial variability of HRs, estimated from fMRI event-related responses elicited during an auditory oddball paradigm in adolescents with ADHD and healthy controls (11-18 years old; N = 46). Adolescents with ADHD had higher HR variability compared with controls in anterior regions of the DMN. This effect was specific to ADHD and not associated with traits of age, IQ and anxiety. However, an ADHD effect of higher HR variability also appeared in a basal ganglia network, but for these brain regions the relationships of HR variability and social anxiety levels were more complex. Performance IIV correlated significantly with variability of HRs in both networks. These results suggest that assessment of trial-to-trial HR variability in ADHD provides information beyond that detectable through analysis of behavioral data and average brain activation levels, revealing specific neural correlates of a possible ADHD IIV endophenotype.
有人提出，注意力及其他认知任务表现中的个体内变异性（IIV）可能是注意力缺陷多动障碍（ADHD）患者的一种认知内表型。尽管行为数据中有大量关于IIV的研究结果，但关于何种类型的脑功能障碍导致反应时间的变异性，相关数据却很稀少。在本研究中，我们探讨了在一项常用的注意力测试中，ADHD患者反应时间的IIV是否可能与逐次试验观察到的血液动力学反应（HRs）变化有关。基于先前将IIV与“默认模式”网络（DMN）内区域联系起来的研究，我们预测，与对照组相比，患有ADHD的青少年在DMN中的HR变异性会更高，而这反过来又会与行为IIV相关。我们还探讨了社交焦虑对ADHD患者HR变异性的影响，以此来检验与高特质焦虑相关的更高唤醒水平是否会影响神经异常。我们评估了HRs的单次试验变异性，这些变异性是根据ADHD青少年和健康对照组（11 - 18岁；N = 46）在听觉Oddball范式中诱发的功能磁共振成像（fMRI）事件相关反应估计得出的。与对照组相比，患有ADHD的青少年在DMN前部区域的HR变异性更高。这种效应是ADHD所特有的，与年龄、智商和焦虑特质无关。然而，在基底神经节网络中也出现了HR变异性更高的ADHD效应，但对于这些脑区，HR变异性与社交焦虑水平的关系更为复杂。在两个网络中，表现IIV均与HRs的变异性显著相关。这些结果表明，评估ADHD患者逐次试验的HR变异性所提供的信息，超出了通过分析行为数据和平均脑激活水平所能检测到的信息，揭示了一种可能的ADHD IIV内表型的特定神经关联。
Zotero 插件