Blackford Jennifer Urbano, Clauss Jacqueline A, Avery Suzanne N, Cowan Ronald L, Benningfield Margaret M, VanDerKlok Ross M
Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, United States; Department of Psychology, Vanderbilt University, Nashville, TN, United States.
Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, United States; Neuroscience Graduate Program, Vanderbilt Brain Institute, Nashville, TN, United States.
Biol Psychol. 2014 May;99:15-25. doi: 10.1016/j.biopsycho.2014.02.003. Epub 2014 Feb 15.
The tendency to approach or avoid novel people is a fundamental human behavior and is a core dimension of social anxiety. Resting state fMRI was used to test for an association between social inhibition and intrinsic connectivity in 40 young adults ranging from low to high in social inhibition. Higher levels of social inhibition were associated with specific patterns of reduced amygdala-cingulate cortex connectivity. Connectivity was reduced between the superficial amygdala and the rostral cingulate cortex and between the centromedial amygdala and the dorsal anterior cingulate cortex. Social inhibition also modulated connectivity in several well-established intrinsic networks; higher social inhibition correlated with reduced connectivity with default mode and dorsal attention networks and enhanced connectivity in salience and executive control networks. These findings provide important preliminary evidence that social inhibition reflects differences in the underlying intrinsic connectivity of the brain in the absence of social stimuli or stressors.
接近或回避陌生人的倾向是一种基本的人类行为，也是社交焦虑的一个核心维度。静息态功能磁共振成像（fMRI）被用于测试40名社交抑制程度从低到高的年轻成年人的社交抑制与内在连接之间的关联。较高水平的社交抑制与杏仁核 - 扣带回皮层连接减少的特定模式相关。浅表杏仁核与喙状扣带回皮层之间以及中央内侧杏仁核与背侧前扣带回皮层之间的连接减少。社交抑制还调节了几个成熟的内在网络中的连接；较高的社交抑制与默认模式网络和背侧注意网络的连接减少以及突显网络和执行控制网络的连接增强相关。这些发现提供了重要的初步证据，表明社交抑制反映了在没有社交刺激或压力源的情况下大脑潜在内在连接的差异。
