股骨近端几何形态作为骨质疏松性髋部骨折女性患者骨折风险因素
Proximal Femoral Geometry as Fracture Risk Factor in Female Patients with Osteoporotic Hip Fracture.
作者信息
Han Jun, Hahn Myung Hoon
机构信息
Department of Orthopeadics, Ajou University School of Medicine, Suwon, Korea.
Department of Orthopaedics, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Cheonan, Korea.
出版信息
J Bone Metab. 2016 Aug;23(3):175-82. doi: 10.11005/jbm.2016.23.3.175. Epub 2016 Aug 31.
BACKGROUND
Proximal femoral geometry may be a risk factor of osteoporotic hip fractures. However, there existed great differences among studies depending on race, sex and age of subjects. The purpose of the present study is to analyze proximal femoral geometry and bone mineral density (BMD) in the osteoporotic hip fracture patients. Furthermore, we investigated proximal femoral geometric parameters affecting fractures, and whether the geometric parameters could be an independent risk factor of fractures regardless of BMD.
METHODS
This study was conducted on 197 women aged 65 years or more who were hospitalized with osteoporotic hip fracture (femur neck fractures ; 84, intertrochanteric fractures; 113). Control group included 551 women who visited to check osteoporosis. Femur BMD and proximal femoral geometry for all subjects were measured using dual energy X-ray absorptiometry (DXA), and compared between the control and fracture groups. Besides, proximal femoral geometric parameters associated with fractures were statistically analyzed.
RESULTS
There were statistically significant differences in the age and weight, cross-sectional area (CSA)/length/width of the femoral neck and BMD of the proximal femur between fracture group and control group. BMD of the proximal femur in the control group was higher than in the fracture group. For the femoral neck fractures group, the odds ratio (OR) for fractures decrease in the CSA and neck length (NL) of the femur increased by 1.97 times and 1.73 times respectively, regardless of BMD. The OR for fractures increase in the femoral neck width increased by 1.53 times. In the intertrochanteric fracture group, the OR for fractures increase in the femoral neck width increased by 1.45 times regardless of BMD.
CONCLUSIONS
We found that an increase of the femoral neck width could be a proximal femoral geometric parameter which plays important roles as a risk factor for fracture independently of BMD.
背景
股骨近端几何形态可能是骨质疏松性髋部骨折的一个危险因素。然而,根据研究对象的种族、性别和年龄不同,各研究之间存在很大差异。本研究的目的是分析骨质疏松性髋部骨折患者的股骨近端几何形态和骨密度(BMD)。此外,我们研究了影响骨折的股骨近端几何参数,以及这些几何参数是否可以成为独立于骨密度的骨折危险因素。
方法
本研究对197名65岁及以上因骨质疏松性髋部骨折住院的女性进行(股骨颈骨折84例,转子间骨折113例)。对照组包括551名前来检查骨质疏松症的女性。使用双能X线吸收法(DXA)测量所有受试者的股骨骨密度和股骨近端几何形态,并在对照组和骨折组之间进行比较。此外,对与骨折相关的股骨近端几何参数进行统计学分析。
结果
骨折组和对照组在年龄、体重、股骨颈的横截面积(CSA)/长度/宽度以及股骨近端骨密度方面存在统计学显著差异。对照组股骨近端骨密度高于骨折组。对于股骨颈骨折组,无论骨密度如何,股骨CSA和颈长(NL)减少时骨折的比值比(OR)分别增加1.97倍和1.73倍。股骨颈宽度增加时骨折的OR增加1.53倍。在转子间骨折组,无论骨密度如何,股骨颈宽度增加时骨折的OR增加1.45倍。
结论
我们发现股骨颈宽度增加可能是一个股骨近端几何参数,它作为骨折的危险因素独立于骨密度发挥重要作用。
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