Kima Peter E
Department of Microbiology and Cell Science, University of Florida, United States.
Cell Immunol. 2016 Nov;309:19-22. doi: 10.1016/j.cellimm.2016.09.004. Epub 2016 Sep 7.
PI3K signaling plays a role in the host response to Leishmania infections. At the cellular level PI3K signaling is engaged by the parasite to control several cellular processes, which ensures parasite persistence. At the systemic level, there is evidence that recruitment of regulatory cells into lesions is impaired in the absence of robust PI3K signaling. In this mini-review the more recent studies that investigated the roles of PI3K signaling in Leishmania infections are discussed.
PI3K信号传导在宿主对利什曼原虫感染的反应中发挥作用。在细胞水平上，寄生虫利用PI3K信号传导来控制多个细胞过程，从而确保寄生虫的持续存在。在系统水平上，有证据表明，在缺乏强大的PI3K信号传导的情况下，调节性细胞向病变部位的募集会受到损害。在这篇小型综述中，将讨论最近研究PI3K信号传导在利什曼原虫感染中作用的研究。
