Zhao Zhiqiang, Liu Xinxia, Xing Xiumei, Lu Yao, Sun Yi, Ou Xiaoyan, Su Xiaolin, Jiang Jun, Yang Yarui, Chen Jingli, Shen Biling, He Yun
Guangzhou Key Laboratory of Environmental Pollution and Risk Assessment, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Prevention and Control Center for Occupational Diseases, Zhongshan Center for Disease Control and Prevention, Zhongshan, Guangdong, China.
PLoS One. 2016 Sep 13;11(9):e0162762. doi: 10.1371/journal.pone.0162762. eCollection 2016.
The objectives of this paper are to study the impact of low level isopropyl alcohol exposure on blood pressure and to explore its potential mechanism.
This cross-sectional study was based on a prospective occupational cohort in south China, which focusing on occupational risk factors related cardiovascular health problems. A total of 283 participants (200 low isopropyl alcohol exposed workers and 83 controls) was finally enrolled in this study. Linear regression models were used to analyze the relationship between arterial blood pressures and low level isopropyl alcohol exposure. We used mediation method to explore possible mediated roles of neurogenic factors.
Systolic blood pressure (SBP, 123±10 vs. 118±11), diastolic blood pressure (DBP, 79±7 vs. 74±7) and mean blood pressure (MBP, 93±8 vs. 89±9) were different between the exposed group and the control group (p < 0.01). After adjusting for covariates, the difference was still significant. Besides, isopropyl alcohol and smoking had an interactive effect on DBP and MBP (p < 0.05). Furthermore, we observed a mediated effect of 5-hydroxyindole acetic acid (5-HIAA) on isopropyl alcohol exposure induced arterial blood pressure increase, which accounted for about 25%.
Our results suggest that low level isopropyl alcohol exposure is a potential risk factor for the increased arterial blood pressure and 5-HIAA partly mediates the association between low level isopropyl alcohol exposure and arterial blood pressures.
本文旨在研究低水平异丙醇暴露对血压的影响，并探讨其潜在机制。
本横断面研究基于中国南方一个前瞻性职业队列，该队列聚焦于与心血管健康问题相关的职业危险因素。本研究最终纳入了283名参与者（200名低水平异丙醇暴露工人和83名对照）。采用线性回归模型分析动脉血压与低水平异丙醇暴露之间的关系。我们使用中介方法来探讨神经源性因素可能的中介作用。
暴露组与对照组的收缩压（SBP，123±10 vs. 118±11）、舒张压（DBP，79±7 vs. 74±7）和平均血压（MBP，93±8 vs. 89±9）存在差异（p < 0.01）。在调整协变量后，差异仍然显著。此外，异丙醇与吸烟对DBP和MBP有交互作用（p < 0.05）。此外，我们观察到5-羟色胺酸（5-HIAA）对异丙醇暴露诱导的动脉血压升高有中介作用，约占25%。
我们的结果表明，低水平异丙醇暴露是动脉血压升高的潜在危险因素，且5-HIAA部分介导了低水平异丙醇暴露与动脉血压之间的关联。
