Arias-Murillo Yazmín Rocío, Osorio-Arango Karime, Cortés Jorge Alberto, Beltrán Mauricio
Subdirección Nacional de Trasplantes y Bancos de Sangre, Dirección de Redes en Salud Pública, Instituto Nacional de Salud, Bogotá, D.C., Colombia.
Biomedica. 2016 May 4;36(0):187-93. doi: 10.7705/biomedica.v36i0.2938.
Cytomegalovirus infections have gained high importance for individuals that have received organ transplants given the clinical implications this may have in immunocompromised patients.
To describe the seroprevalence of cytomegalovirus in organ donors and recipients of kidney transplants nationwide from the six regions established by the Red Nacional de Donación y Trasplante.
We conducted a descriptive retrospective study that included 1,813 organ donors and 3,313 recipients of kidney transplants, and we calculated IgM and IgG seroprevalence for cytomegalovirus. IgG prevalence was stratified according to sex, age group, and region, and the results were analyzed in each donor-recipient pair and classified according to the risk. Statistical packages IBM SPSS®, Statistics 22, and Epi Info 7 were utilized.
IgG prevalence for cytomegalivirus was 86.8% in donors and 91.0% in kidney transplant recipients with statistical significance observed for age, geographical location, and between donors and recipients. We analyzed 1,764 pairs of donors and recipients, of which 91.4% were categorized as having intermediate risk.
The results of this study showed high cytomegalovirus infection rates in Colombia. Given the risk, categorization of patients undergoing transplants, measures should be adopted by medical teams to minimize risks.
鉴于巨细胞病毒感染对免疫功能低下患者可能产生的临床影响，其对于接受器官移植的个体具有高度重要性。
描述全国范围内由国家器官捐赠与移植网络设立的六个地区的器官捐赠者和肾移植受者中巨细胞病毒的血清流行率。
我们进行了一项描述性回顾性研究，纳入了1813名器官捐赠者和3313名肾移植受者，并计算了巨细胞病毒的IgM和IgG血清流行率。IgG流行率根据性别、年龄组和地区进行分层，并在每对捐赠者 - 受者中分析结果并根据风险进行分类。使用了IBM SPSS® Statistics 22和Epi Info 7统计软件包。
巨细胞病毒的IgG流行率在捐赠者中为86.8%，在肾移植受者中为91.0%，在年龄、地理位置以及捐赠者和受者之间观察到统计学意义。我们分析了1764对捐赠者和受者，其中91.4%被归类为具有中度风险。
本研究结果显示哥伦比亚的巨细胞病毒感染率很高。鉴于这种风险以及对移植患者的分类，医疗团队应采取措施将风险降至最低。
