Das Bankim, Kaur Gagandeep, Basu Sabita
Department of Transfusion Medicine, Gian Sagar Medical College, Rajpura, India.
Department of Transfusion Medicine, Government Medical College and Hospital, Chandigarh, India.
Transfus Apher Sci. 2014 Jun;50(3):438-42. doi: 10.1016/j.transci.2014.02.022. Epub 2014 Mar 12.
Primary Cytomegalovirus infection caused by transfusion is a major problem for immunocompromised CMV seronegative patients. Documentation of the status of antibodies to cytomegalovirus in the blood donor pool population is vital to the understanding of the potential likelihood of transmission through donor blood and for determining the best transfusion practices to prevent TT-CMV infection. The present study was conducted to determine the prevalence of CMV infection among blood donors and Multitransfused recipients of north Indian population.
A prospective study was done on 2100 donors' samples and 200 patients sample for CMV antibodies using the ELISA technique.
Out of 2100 donors recruited, 93.8% males and 6.2% females. 98.6% were positive for anti CMV IgG antibodies and only one donor was positive for anti CMV IgM antibody. In Multitransfused patients, out of 200 patients, seroprevalence for anti CMV IgG antibodies was in 100% patients and only one patient was positive for anti CMV IgM antibody.
The study did not demonstrate statistical significant influence of age and gender on prevalence of anti CMV IgG and IgM antibodies. Other preventive strategies such as universal leucodepletion may be implemented to prevent transmission of CMV in immunocompromised patients.
输血导致的原发性巨细胞病毒感染是免疫功能低下的巨细胞病毒血清学阴性患者面临的一个主要问题。记录献血人群中巨细胞病毒抗体状态对于了解通过献血传播的潜在可能性以及确定预防输血传播巨细胞病毒感染的最佳输血措施至关重要。本研究旨在确定印度北部人群中献血者和多次输血受血者的巨细胞病毒感染率。
采用酶联免疫吸附测定（ELISA）技术对2100份献血者样本和200份患者样本进行巨细胞病毒抗体的前瞻性研究。
在招募的2100名献血者中，男性占93.8%，女性占6.2%。98.6%的献血者抗巨细胞病毒IgG抗体呈阳性，只有1名献血者抗巨细胞病毒IgM抗体呈阳性。在多次输血患者中，200名患者中抗巨细胞病毒IgG抗体的血清阳性率为100%，只有1名患者抗巨细胞病毒IgM抗体呈阳性。
该研究未显示年龄和性别对抗巨细胞病毒IgG和IgM抗体感染率有统计学上的显著影响。可实施其他预防策略，如普遍白细胞滤除，以预防免疫功能低下患者中巨细胞病毒的传播。
