Akindiose Cathlyn, Alatise Olusegun Isaac, Arowolo Olukayode Adeolu, Agbakwuru Augustine E
Department of Surgery, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.
Department of Surgery, College of Health Sciences, Obafemi Awolowo University/Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.
Niger Postgrad Med J. 2016 Jul-Sep;23(3):110-5. doi: 10.4103/1117-1936.190347.
The objective of this study was to compare the efficacy and safety of 5% phenol in almond oil with 50% dextrose water as sclerosants in the treatment of first- to third-degree haemorrhoids.
This was a prospective, comparative study conducted on eighty patients with first-, second- and third-degree haemorrhoids who consented to treatment by injection sclerotherapy with either 5% phenol in almond oil or 50% dextrose water. They were randomised equally into two groups.
A total of eighty patients including 58 males and 22 females whose age ranged from 19 to 61 years were included in the study. Bleeding was the chief symptom which was present in 78 (97.5%) patients, and there was complete resolution of this in 92.3% and 89.7% in the 5% phenol in almond oil and 50% dextrose water groups, respectively, at 6 months (P = 0.905). Similar degrees of resolution were noted for anal protrusion (89.1% and 85.3% in the 5% phenol in almond oil and 50% dextrose water group, respectively, P = 0.899). The overall complication rate was 3.6% with anal mucosa ulceration being the only complication, occurring in three patients who had 5% phenol in almond oil. Peri-procedure pain, patients satisfaction and acceptability were not significantly different in both groups (P = 0.912, 0.928 and 0.926 respectively).
Five percent phenol in almond oil and 50% dextrose water are equally effective sclerosants in the treatment of haemorrhoids with very low complication rates.
本研究的目的是比较5%杏仁油酚与50%葡萄糖水作为硬化剂治疗一至三度痔疮的疗效和安全性。
这是一项前瞻性比较研究，对80例同意采用5%杏仁油酚或50%葡萄糖水注射硬化疗法治疗的一、二、三度痔疮患者进行。他们被平均随机分为两组。
本研究共纳入80例患者，其中男性58例，女性22例，年龄在19至61岁之间。出血是主要症状，78例（97.5%）患者出现该症状，6个月时，5%杏仁油酚组和50%葡萄糖水组的出血症状完全缓解率分别为92.3%和89.7%（P = 0.905）。肛门突出的缓解程度相似（5%杏仁油酚组和50%葡萄糖水组分别为89.1%和85.3%，P = 0.899）。总体并发症发生率为3.6%，唯一的并发症是肛门黏膜溃疡，发生在3例接受5%杏仁油酚治疗的患者中。两组围手术期疼痛、患者满意度和可接受性无显著差异（分别为P = 0.912、0.928和0.926）。
5%杏仁油酚和50%葡萄糖水是治疗痔疮同样有效的硬化剂，并发症发生率极低。
