硝基卟啉和硝基corrole作为抗人巨细胞病毒感染潜在药物的合成及抗病毒活性评估
Synthesis and Antiviral Activity Evaluation of Nitroporphyrins and Nitrocorroles as Potential Agents against Human Cytomegalovirus Infection.
作者信息
Gros Claude P, Desbois Nicolas, Michelin Clément, Demilly Eloise, Tilkin-Mariamé Anne-Françoise, Mariamé Bernard, Gallardo Franck
机构信息
ICMUB (UMR CNRS 6302), Université de Bourgogne Franche-Comté , 9 Avenue Alain Savary, B.P. 47 870, 21078 Dijon Cedex, France.
Institut des Technologies Avancées en Sciences du Vivant (CNRS USR3505), 1 place Pierre Potier, Oncopole, entrée B, 31106 Toulouse, France.
出版信息
ACS Infect Dis. 2015 Aug 14;1(8):350-6. doi: 10.1021/acsinfecdis.5b00020. Epub 2015 Jun 2.
Different nitroporphyrinoid derivatives were synthesized and studied as potential agents against human Cytomegalovirus. Interestingly, two nitrocorroles display strong activity against human Cytomegalovirus with IC 50 < 0.5 μM. These compounds also possess antiproliferative activities without detected in vivo toxicity. Therefore, nitrocorroles appear for the first time as potential active compounds that can be applied in human health.
合成了不同的硝基卟啉类衍生物，并将其作为抗人巨细胞病毒的潜在药物进行研究。有趣的是，两种硝基卟吩对人巨细胞病毒表现出很强的活性，IC50 < 0.5 μM。这些化合物还具有抗增殖活性，且未检测到体内毒性。因此，硝基卟吩首次作为可应用于人类健康的潜在活性化合物出现。
Zotero 插件