一种用于癌症风险评估的随机两阶段模型。II. 癌前克隆的数量和大小。
A stochastic two-stage model for cancer risk assessment. II. The number and size of premalignant clones.
作者信息
Dewanji A, Venzon D J, Moolgavkar S H
机构信息
Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington 98104.
出版信息
Risk Anal. 1989 Jun;9(2):179-87. doi: 10.1111/j.1539-6924.1989.tb01238.x.
Abstract
Mathematical expressions are derived, under different dosing patterns, for the number and size of premalignant clones within the framework of a two-mutation model for carcinogenesis, which has previously been shown to be consistent with a large body of epidemiologic and experimental data.
摘要
在不同给药模式下，针对癌变的双突变模型框架内癌前克隆的数量和大小推导了数学表达式，该模型先前已被证明与大量流行病学和实验数据一致。
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