一种用于癌症风险评估的随机两阶段模型。I. 风险函数与肿瘤概率。
A stochastic two-stage model for cancer risk assessment. I. The hazard function and the probability of tumor.
作者信息
Moolgavkar S H, Dewanji A, Venzon D J
机构信息
Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
出版信息
Risk Anal. 1988 Sep;8(3):383-92. doi: 10.1111/j.1539-6924.1988.tb00502.x.
Abstract
We present a mathematical treatment of a two-mutation model for carcinogenesis with time-dependent parameters. This model has previously been shown to be consistent with epidemiologic and experimental data. An approximate hazard function used in previous papers is critically evaluated.
摘要
我们给出了一个具有时间依赖参数的癌症发生双突变模型的数学处理方法。该模型先前已被证明与流行病学和实验数据一致。对先前论文中使用的近似风险函数进行了严格评估。
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