Chomette G, Auriol M, Vidal J M, Soudant J
Service d'Anatomie Pathologique, Hôpital de la Pitié, Paris.
Rev Stomatol Chir Maxillofac. 1989;90(4):293-6.
A case of undifferentiated epithelioma of the left parotid gland occurred 2 years after the removal of a cystadenolymphoma in the right parotid gland. The relationship of these two tumours was supported by several statements: the immunohistochemical study demonstrated in the epithelial cells of the 2 neoplasms the existence of ACE, usually thought as characteristic of cystadenolymphoma. Besides, it showed a high number of plasma cells secreting IgA in the stroma of the 2 tumours, the ultrastructural study performed on the epithelioma also demonstrated some similarities between epitheliomatous cells and epithelial cells of cystadenolymphomas (outlined epidermoid or glandular differentiation, numerous mitochondria). A peculiar, perhaps immunological mechanism could induce the cancerization, according to the theories used to explain the histogenesis of cystadenolymphoma.
1例左腮腺未分化上皮瘤发生于右腮腺腺淋巴瘤切除术后2年。这两种肿瘤的关系得到了以下几点支持:免疫组化研究显示,这两种肿瘤的上皮细胞中均存在血管紧张素转换酶(ACE),而ACE通常被认为是腺淋巴瘤的特征。此外,在这两种肿瘤的间质中均发现大量分泌IgA的浆细胞,对上皮瘤进行的超微结构研究也显示上皮瘤细胞与腺淋巴瘤的上皮细胞之间存在一些相似之处(呈现出表皮样或腺性分化,线粒体众多)。根据用于解释腺淋巴瘤组织发生的理论,一种特殊的、可能是免疫机制可诱导癌变。