Roynard P F P, Bilderback A, Falzone C, Stefanacci J D, Cherubini G B
Long Island Veterinary Specialists, Plainview, NY, 11803, USA.
Fipapharm, 76130, Mont-Saint-Aignan, France.
J Small Anim Pract. 2016 Nov;57(11):610-616. doi: 10.1111/jsap.12554. Epub 2016 Sep 14.
To report the clinical presentation, magnetic resonance imaging features, treatments and outcomes of canine vertebral chondrosarcoma.
Retrospective review of medical records of dogs with confirmed vertebral chondrosarcoma and magnetic resonance imaging of the lesions, from four different veterinary referral institutions.
A total of six dogs were included in this report. In all cases, magnetic resonance imaging revealed a lobulated mass involving the dorsal vertebral compartment, markedly hyperintense with few foci of hypointensity on T2-weighted images, iso to hypointense on T1-weighted images with contrast enhancement after gadolinium administration. Intralesional surgical resection was performed in three dogs and medical management in one, two dogs were euthanased and all lesions were submitted for histopathology. Magnetic resonance imaging findings correlated with histological findings of a low tumour grade. Rapid clinical improvement was noted after surgery but two of three dogs had local regrowth.
Chondrosarcomas show local aggressiveness and resistance to conventional radiotherapy and chemotherapy, and so prognosis depends on feasibility of en bloc resection. Magnetic resonance imaging may be helpful in establishing a presumptive diagnosis and prognosis based on the feasibility of surgical resection.
报告犬椎体软骨肉瘤的临床表现、磁共振成像特征、治疗方法及结果。
回顾来自四个不同兽医转诊机构确诊为椎体软骨肉瘤的犬的病历及病变的磁共振成像。
本报告共纳入6只犬。所有病例中，磁共振成像显示一个分叶状肿块累及椎体背侧部分，在T2加权图像上明显高信号，有少数低信号灶，在T1加权图像上等信号至低信号，注射钆后有对比增强。3只犬进行了病灶内手术切除，1只进行了药物治疗，2只犬实施了安乐死，所有病变均进行了组织病理学检查。磁共振成像结果与低肿瘤分级的组织学结果相关。术后临床症状迅速改善，但3只犬中有2只出现局部复发。
软骨肉瘤表现出局部侵袭性以及对传统放疗和化疗的耐药性，因此预后取决于整块切除的可行性。磁共振成像可能有助于根据手术切除的可行性建立初步诊断和预后判断。
