Shimada Masakazu, Nagashima Tomokazu, Michishita Masaki, Yazawa Daisuke, Hara Yasushi
Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Tokyo, Japan.
Division of Veterinary Pathology, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Tokyo, Japan.
Front Vet Sci. 2023 Apr 3;10:966513. doi: 10.3389/fvets.2023.966513. eCollection 2023.
Chondrosarcoma is the second most common primary bone tumor after osteosarcoma in dogs. Chondrosarcoma has a good prognosis owing to its low metastatic rate and long survival time, even with amputation alone. However, amputation risks reducing the quality of life in patients with other orthopedic diseases of the non-affected limb, neurological diseases, or large body size. Limb-sparing surgery with frozen autologous bone grafting using liquid nitrogen allows bone quality to be maintained in the normal bone area while killing tumor cells, thereby preserving the affected limb. Thus, it is expected to maintain the quality of life. We describe herein limb-sparing surgery for tibial chondrosarcoma with frozen autologous bone graft using liquid nitrogen in an 8-year and 8-month-old castrated male bulldog weighing 29.2 kg. The patient had chondrosarcoma of the left tibia, suspected cranial cruciate ligament rupture of the right stifle, and degenerative lumbosacral stenosis. In such a case, amputation would increase the burden on the non-affected limb or spine, which could cause difficulty in walking; therefore, we performed limb-sparing surgery. Postoperatively, although a circumduction gait associated with stifle arthrodesis remained, the patient maintained the quality of life for 20 months, and the owner was satisfied with the results.
软骨肉瘤是犬类继骨肉瘤之后第二常见的原发性骨肿瘤。软骨肉瘤预后良好，因其转移率低且生存时间长，即便仅行截肢手术亦是如此。然而，截肢有降低非患侧肢体患有其他骨科疾病、神经疾病或体型较大患者生活质量的风险。采用液氮冷冻自体骨移植的保肢手术可在杀死肿瘤细胞的同时，使正常骨区域的骨质得以维持，从而保留患侧肢体。因此，有望维持生活质量。在此，我们描述了一例8岁8个月、体重29.2千克的去势雄性斗牛犬，采用液氮冷冻自体骨移植对其胫骨软骨肉瘤进行保肢手术的过程。该患者患有左胫骨软骨肉瘤、右膝关节疑似颅侧交叉韧带断裂以及退行性腰骶部椎管狭窄。在此种情况下，截肢会增加非患侧肢体或脊柱的负担，可能导致行走困难；因此，我们实施了保肢手术。术后，尽管仍存在与膝关节融合相关的环行步态，但患者维持了20个月的生活质量，且主人对结果满意。
