Zhu Jinzhou, Wan Xingyong, Wang Yuming, Zhu Kefu, Li Chunxiao, Yu Chaohui, Li Youming
Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang Province, China.
The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310003, Zhejiang Province, China.
Endocrine. 2017 Apr;56(1):208-211. doi: 10.1007/s12020-016-1112-5. Epub 2016 Sep 14.
Fetuin is an endogenous inhibitor of the insulin receptor tyrosine kinase. Recent studies supported the possible role of fetuin B in metabolic diseases. This study is to evaluate the role of serum fetuin B in nonalcoholic fatty liver disease (NAFLD). A hospital-based case-control study of 184 subjects was conducted. Serum level of fetuin B was measured by enzyme-linked immunosorbent assay. The serum level of fetuin B in the control (91.0 ± 36.9 μg/ml) was lower than it in NAFLD (108.7 ± 38.5 μg/ml, P < 0.001). The percentage of NAFLD increased (42.9%, 58.7% and 60.2%; P < 0.001; linear-by-linear association: P < 0.001), as fetuin B concentration elevated in its tertiles, after adjustment of body mass index (BMI). Furthermore, compared with the 1st tertile, the 3rd tertile of fetuin B indicated an association with the presence of NAFLD (adjusted odds ratio = 2.087, 95% confidence interval [1.016 - 3.937], P = 0.023), after controlling age, sex, BMI, diabetes, hypertension and hypertriglyceridemia. Lastly, fetuin B correlated with diastolic blood pressure, serum alanine transaminase and triglycerides, among the controls. It suggested a potential association between serum fetuin B and the presence of NAFLD.
胎球蛋白是胰岛素受体酪氨酸激酶的内源性抑制剂。最近的研究支持了胎球蛋白B在代谢性疾病中的可能作用。本研究旨在评估血清胎球蛋白B在非酒精性脂肪性肝病（NAFLD）中的作用。对184名受试者进行了一项基于医院的病例对照研究。采用酶联免疫吸附测定法检测血清胎球蛋白B水平。对照组血清胎球蛋白B水平（91.0±36.9μg/ml）低于非酒精性脂肪性肝病组（108.7±38.5μg/ml，P<0.001）。在调整体重指数（BMI）后，随着胎球蛋白B浓度在其三分位数中升高，非酒精性脂肪性肝病的百分比增加（42.9%、58.7%和60.2%；P<0.001；线性趋势检验：P<0.001）。此外，表示胎球蛋白B的第三个三分位数与非酒精性脂肪性肝病的存在相关（调整后的比值比=2.087，95%置信区间[1.016 - 3.937]，P = 0.023），在控制年龄、性别、BMI、糖尿病、高血压和高甘油三酯血症之后。最后，在对照组中，胎球蛋白B与舒张压、血清丙氨酸转氨酶和甘油三酯相关。这表明血清胎球蛋白B与非酒精性脂肪性肝病的存在之间存在潜在关联。
