Tanaka Kenichiro, Nakayasu Hiroyuki, Suto Yutaka, Takahashi Shotaro, Konishi Yoshihiro, Nishimura Hirotake, Ueno Rino, Kusunoki Susumu, Nakashima Kenji
Department of Neurology, Tottori Prefectural Central Hospital, Japan.
Intern Med. 2016;55(18):2717-22. doi: 10.2169/internalmedicine.55.6881. Epub 2016 Sep 15.
A patient with xerostomia and xerophthalmia due to Sjögren's syndrome presented with acute motor-dominant polyneuropathy and multiple mononeuropathy with antiganglioside antibodies. Nerve conduction studies and a sural nerve biopsy revealed the neuropathy as a mixture of segmental demyelination and axonal degeneration. Positive results were obtained for several antiganglioside antibodies. Corticosteroid treatment proved effective. The neuropathy was considered to represent a mixture of polyneuropathy as Guillain-Barré syndrome and multiple mononeuropathy via Sjögren's syndrome. We speculate that Guillain-Barré syndrome occurred in the patient and Guillain-Barré syndrome itself activated multiple mononeuropathy via Sjögren's syndrome.
一名因干燥综合征导致口干和眼干的患者出现了以急性运动为主的多神经病和伴有抗神经节苷脂抗体的多发性单神经病。神经传导研究和腓肠神经活检显示，该神经病为节段性脱髓鞘和轴索性变性的混合表现。多种抗神经节苷脂抗体检测呈阳性。皮质类固醇治疗证明有效。该神经病被认为是吉兰 - 巴雷综合征样的多神经病和通过干燥综合征导致的多发性单神经病的混合表现。我们推测该患者发生了吉兰 - 巴雷综合征，且吉兰 - 巴雷综合征本身通过干燥综合征激活了多发性单神经病。
