补体C4d在食管鳞状细胞癌中的表达意义

Significance of Expression of Complement C4d in Esophageal Squamous Cell Carcinoma.

作者信息

Kikuchi Maiko, Nakajima Masanobu, Muroi Hiroto, Takahashi Masakazu, Itoh Jun, Yamaguchi Satoru, Sasaki Kinro, Kato Hiroyuki

机构信息

Department of Surgery I, Dokkyo Medical University, Mibu, Japan

Department of Surgery I, Dokkyo Medical University, Mibu, Japan.

出版信息

Anticancer Res. 2016 Sep;36(9):4553-7. doi: 10.21873/anticanres.11003.

DOI:10.21873/anticanres.11003

PMID:27630295

Abstract

BACKGROUND/AIM: Esophageal squamous cell carcinoma (ESCC) is one of the most difficult malignancies to cure. C4d is a degradation product of the classical complement pathway and is suggested as an early diagnostic marker for other SCCs. The purpose of this study was to clarify the association of complement C4d with ESCC.

PATIENTS AND METHODS

Immunohistochemical staining for C4d was performed on surgical specimens obtained from 114 patients with ESCC.

RESULTS

Positive C4d expression was observed in 70 (61.4%) cases and negative expression in 44 (38.6%) cases. There was a significant inverse correlation between C4d expression and depth of tumor invasion (p=0.0001), lymph node metastasis (p=0.011), lymphatic invasion (p=0.033), and TNM stage (p=0.0021). Kaplan-Meier analysis showed that negative C4d expression tended to lead to shorter overall survival (p=0.232).

CONCLUSION

C4d expression in ESCC might be useful in developing treatment strategies or suppression of ESCC.

摘要

背景/目的：食管鳞状细胞癌（ESCC）是最难治愈的恶性肿瘤之一。C4d是经典补体途径的降解产物，被认为是其他鳞状细胞癌的早期诊断标志物。本研究的目的是阐明补体C4d与ESCC的关联。

患者与方法

对114例ESCC患者的手术标本进行C4d免疫组化染色。

结果

70例（61.4%）病例C4d表达阳性，44例（38.6%）病例表达阴性。C4d表达与肿瘤浸润深度（p=0.0001）、淋巴结转移（p=0.011）、淋巴管浸润（p=0.033）及TNM分期（p=0.0021）之间存在显著负相关。Kaplan-Meier分析显示，C4d表达阴性往往导致总生存期缩短（p=0.232）。