Zhang Yan, Liao Ruyi, Li Hui, Liu Ling, Chen Xiao, Chen Hongming
Institute of International Education, College of Basic Medical Sciences, Xinjiang Medical University, Urumqi, Xinjiang, China (mainland).
Department of Gastroenterology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China (mainland).
Med Sci Monit. 2015 Sep 7;21:2659-65. doi: 10.12659/MSM.895242.
Esophageal squamous cell carcinoma (ESCC) has attracted much research attention around the world, and the number of ESCC cases has increased gradually in recent years. Identifying the specific biomarkers of ESCC is an effective approach for the early diagnosis of tumors.
Immunohistochemical streptavidin-peroxidase method was used to determine the expressions of Cofilin-1 and transgelin in 68 patients with esophageal squamous cell carcinoma (ESCC) and 48 individuals with normal esophageal tissues. In addition to the relationships between the expression of Cofilin-1 and transgelin, the clinicopathologic features of ESCC were also discussed. The correlation between Cofilin-1 and transgelin protein expression in ESCC was analyzed.
(1) The positive expression rates of Cofilin-1 and transgelin were 60.3% (41/68) and 54.4% (37/68) in esophageal carcinoma tissue, respectively. The positive expression rates of Cofilin-1 and transgelin in normal esophageal tissue were 27.1% (13/48) and 29.1% (14/48), respectively. The differences were statistically significant (P<0.05). (2) The positive expression rate of Cofilin-1 did not differ significantly (P>0.05) with sex, age, ethnicity, tumor size, or infiltration depth; but did have a statistically significant (P<0.05) difference with various degrees of tumor differentiation, lymph node metastasis, and clinical stages. (3) The positive expression rate of transgelin did not differ significantly (P>0.05) with sex, age, ethnicity, tumor size, infiltration depth, and clinical stage, but did significantly (P<0.05) differ with degree of tumor differentiation and lymph node metastasis.
Cofilin-1 and transgelin may play roles in the carcinogenesis and development of esophageal squamous cell carcinoma. Cofilin-1 may be useful as an important biomarker for indicating the degree of malignancy of esophageal squamous cell carcinoma, and the detection of transgelin is valuable in early diagnosis of esophageal squamous cell carcinoma.
食管鳞状细胞癌（ESCC）已引起全球众多研究关注，近年来ESCC病例数逐渐增加。确定ESCC的特异性生物标志物是肿瘤早期诊断的有效方法。
采用免疫组织化学链霉亲和素-过氧化物酶法检测68例食管鳞状细胞癌（ESCC）患者及48例正常食管组织个体中Cofilin-1和原肌球蛋白的表达。除了Cofilin-1和原肌球蛋白表达之间的关系外，还讨论了ESCC的临床病理特征。分析了ESCC中Cofilin-1与原肌球蛋白蛋白表达的相关性。
（1）食管癌组织中Cofilin-1和原肌球蛋白的阳性表达率分别为60.3%（41/68）和54.4%（37/68）。正常食管组织中Cofilin-1和原肌球蛋白的阳性表达率分别为27.1%（13/48）和29.1%（14/48）。差异具有统计学意义（P<0.05）。（2）Cofilin-1的阳性表达率在性别、年龄、种族、肿瘤大小或浸润深度方面无显著差异（P>0.05）；但在不同程度的肿瘤分化、淋巴结转移和临床分期方面存在统计学显著差异（P<0.05）。（3）原肌球蛋白的阳性表达率在性别、年龄、种族、肿瘤大小、浸润深度和临床分期方面无显著差异（P>0.05），但在肿瘤分化程度和淋巴结转移方面有显著差异（P<0.05）。
Cofilin-1和原肌球蛋白可能在食管鳞状细胞癌的发生发展中起作用。Cofilin-1可能作为指示食管鳞状细胞癌恶性程度的重要生物标志物，而检测原肌球蛋白对食管鳞状细胞癌的早期诊断有价值。
