Thakkar Dhaval J, Deshpande Neeraj C, Dave Deepak H, Narayankar Suraj D
Department of Periodontics, K.M. Shah Dental College and Hospital, Sumandeep Vidyapeeth, Vadodara, Gujarat, India.
Contemp Clin Dent. 2016 Jul-Sep;7(3):371-6. doi: 10.4103/0976-237X.188567.
To investigate clinically and radiographically, the bone fill in extraction sockets using demineralized freeze-dried bone allograft alone and along with platelet-rich fibrin (PRF).
A randomized controlled clinical trial was carried out on 36 nonrestorable single-rooted teeth sites. Sites were randomized into demineralized freeze-dried bone allograft (DFDBA) combined with PRF - test and DFDBA - control groups using a coin toss method. After the placement of graft material, collagen membrane was used to cover it. The clinical parameters recorded were ridge width and ridge height. All the parameters were recorded at baseline and at 90 and 180 days.
Independent t-test and paired t-test.
In both groups, there is significant reduction in loss of ridge width and ridge height from baseline to 90 days (P < 0.001), baseline to 180 days (P < 0.001), and 90-180 days (P < 0.001). However, when both the groups were compared the test group favored in the reduction of ridge width while there was no statistical difference in reduction of ridge height among at different intervals.
Although DFDBA is considered as an ideal graft material, PRF can be used as an adjunctive with DFDBA for socket preservation.
通过临床和影像学研究，单独使用脱矿冻干骨同种异体移植物以及联合富血小板纤维蛋白（PRF）时，拔牙窝内的骨填充情况。
对36个不可修复的单根牙部位进行了一项随机对照临床试验。采用抛硬币法将这些部位随机分为脱矿冻干骨同种异体移植物（DFDBA）联合PRF试验组和DFDBA对照组。植入移植材料后，使用胶原膜覆盖。记录的临床参数为牙槽嵴宽度和牙槽嵴高度。所有参数均在基线、90天和180天时记录。
独立t检验和配对t检验。
两组中，从基线到90天（P < 0.001）、基线到180天（P < 0.001）以及90至180天（P < 0.001），牙槽嵴宽度和牙槽嵴高度的损失均有显著减少。然而，比较两组时，试验组在牙槽嵴宽度减少方面更具优势，而在不同时间段牙槽嵴高度减少方面无统计学差异。
尽管DFDBA被认为是一种理想的移植材料，但PRF可作为DFDBA的辅助材料用于牙槽窝保存。
