Lum Su Han, Turner Andrew, Guiver Malcolm, Bonney Denise, Martland Timorthy, Davies Emma, Newbould Melanie, Brown Julianne, Morfopoulou Sofia, Breuer Judith, Wynn Robert
Department of Blood and Marrow Transplant, Royal Manchester Children's Hospital, Manchester, UK.
Clinical Virology Department, Manchester Royal Infirmary, Manchester, UK.
Transpl Infect Dis. 2016 Dec;18(6):960-964. doi: 10.1111/tid.12607. Epub 2016 Oct 27.
Neuroinvasive astrovirus (VA1-HMO-C) is an emerging life-threatening infection in immunocompromised hosts. We describe an 8-month-old child who died of VA1/HMO-C encephalitis following bone marrow transplantation. The diagnosis was only made post-mortem using RNA deep sequencing of the brain. Repeat analysis of the post-mortem brain tissue using polymerase chain reaction specific primers for VA1/HMO-C was positive. Astrovirus VA1/HMO-C should be included in the evaluation of patients with similar encephalitis.
神经侵袭性星状病毒（VA1-HMO-C）是一种在免疫功能低下宿主中出现的危及生命的感染。我们描述了一名8个月大的儿童，其在骨髓移植后死于VA1/HMO-C脑炎。诊断仅在死后通过对大脑进行RNA深度测序做出。使用针对VA1/HMO-C的聚合酶链反应特异性引物对死后脑组织进行重复分析呈阳性。VA1/HMO-C星状病毒应纳入对患有类似脑炎患者的评估中。
