Suppr超能文献

委内瑞拉马脑炎病毒和西部马脑炎病毒E1脂质体抗原核酸复合物可保护小鼠免受多种甲病毒的致死性攻击。

Venezuelan and western equine encephalitis virus E1 liposome antigen nucleic acid complexes protect mice from lethal challenge with multiple alphaviruses.

作者信息

Rico Amber B, Phillips Aaron T, Schountz Tony, Jarvis Donald L, Tjalkens Ronald B, Powers Ann M, Olson Ken E

机构信息

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.

出版信息

Virology. 2016 Dec;499:30-39. doi: 10.1016/j.virol.2016.08.023. Epub 2016 Sep 12.

DOI:10.1016/j.virol.2016.08.023
PMID:27632563
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5884135/
Abstract

Eastern, Venezuelan and western equine encephalitis viruses (EEEV, VEEV, and WEEV) are mosquito-borne viruses that cause substantial disease in humans and other vertebrates. Vaccines are limited and current treatment options have not proven successful. In this report, we vaccinated outbred mice with lipid-antigen-nucleic acid-complexes (LANACs) containing VEEV E1+WEEV E1 antigen and characterized protective efficacy against lethal EEEV, VEEV, and WEEV challenge. Vaccination resulted in complete protection against EEEV, VEEV, and WEEV in CD-1 mice. Measurements of bioluminescence and plaque reduction neutralization tests (PRNTs) indicate that LANAC VEEV E1+WEEV E1 vaccination is sterilizing against VEEV and WEEV challenge; whereas immunity to EEEV is not sterilizing. Passive transfer of rabbit VEEV E1+WEEV E1 immune serum to naive mice extended the mean time to death (MTD) of EEEV challenged mice and provided significant protection from lethal VEEV and WEEV challenge.

摘要

东部、委内瑞拉和西部马脑炎病毒（EEEV、VEEV和WEEV）是蚊媒病毒，可在人类和其他脊椎动物中引发严重疾病。疫苗有限，目前的治疗方案尚未证明有效。在本报告中，我们用含有VEEV E1+WEEV E1抗原的脂质-抗原-核酸复合物（LANACs）对远交系小鼠进行免疫接种，并对其针对致死性EEEV、VEEV和WEEV攻击的保护效果进行了表征。接种疫苗使CD-1小鼠对EEEV、VEEV和WEEV产生了完全保护。生物发光测量和蚀斑减少中和试验（PRNTs）表明，LANAC VEEV E1+WEEV E1免疫接种对VEEV和WEEV攻击具有杀菌作用；而对EEEV的免疫不是杀菌性的。将兔VEEV E1+WEEV E1免疫血清被动转移至未免疫小鼠，延长了受EEEV攻击小鼠的平均死亡时间（MTD），并为其提供了针对致死性VEEV和WEEV攻击的显著保护。

相似文献

1
Venezuelan and western equine encephalitis virus E1 liposome antigen nucleic acid complexes protect mice from lethal challenge with multiple alphaviruses.
Virology. 2016 Dec;499:30-39. doi: 10.1016/j.virol.2016.08.023. Epub 2016 Sep 12.
2
Liposome-antigen-nucleic acid complexes protect mice from lethal challenge with western and eastern equine encephalitis viruses.
J Virol. 2014 Feb;88(3):1771-80. doi: 10.1128/JVI.02297-13. Epub 2013 Nov 20.
3
A Monovalent and Trivalent MVA-Based Vaccine Completely Protects Mice Against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenge.
Front Immunol. 2021 Jan 19;11:598847. doi: 10.3389/fimmu.2020.598847. eCollection 2020.
4
Novel Insect-Specific Eilat Virus-Based Chimeric Vaccine Candidates Provide Durable, Mono- and Multivalent, Single-Dose Protection against Lethal Alphavirus Challenge.
J Virol. 2018 Jan 30;92(4). doi: 10.1128/JVI.01274-17. Print 2018 Feb 15.
5
Recombinant Isfahan Virus and Vesicular Stomatitis Virus Vaccine Vectors Provide Durable, Multivalent, Single-Dose Protection against Lethal Alphavirus Challenge.
J Virol. 2017 Mar 29;91(8). doi: 10.1128/JVI.01729-16. Print 2017 Apr 15.
6
Entry Sites of Venezuelan and Western Equine Encephalitis Viruses in the Mouse Central Nervous System following Peripheral Infection.
J Virol. 2016 May 27;90(12):5785-96. doi: 10.1128/JVI.03219-15. Print 2016 Jun 15.
7
Exposing cryptic epitopes on the Venezuelan equine encephalitis virus E1 glycoprotein prior to treatment with alphavirus cross-reactive monoclonal antibody allows blockage of replication early in infection.
Virology. 2022 Jan 2;565:13-21. doi: 10.1016/j.virol.2021.09.007. Epub 2021 Sep 28.
8
Combined alphavirus replicon particle vaccine induces durable and cross-protective immune responses against equine encephalitis viruses.
J Virol. 2014 Oct;88(20):12077-86. doi: 10.1128/JVI.01406-14. Epub 2014 Aug 13.
9
A Multiagent Alphavirus DNA Vaccine Delivered by Intramuscular Electroporation Elicits Robust and Durable Virus-Specific Immune Responses in Mice and Rabbits and Completely Protects Mice against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenges.
J Immunol Res. 2018 Jun 3;2018:8521060. doi: 10.1155/2018/8521060. eCollection 2018.
10
Directed molecular evolution improves the immunogenicity and protective efficacy of a Venezuelan equine encephalitis virus DNA vaccine.
Vaccine. 2009 Jun 24;27(31):4152-60. doi: 10.1016/j.vaccine.2009.04.049. Epub 2009 May 9.

引用本文的文献

1
Vaccine elicitation and structural basis for antibody protection against alphaviruses.
Cell. 2023 Jun 8;186(12):2672-2689.e25. doi: 10.1016/j.cell.2023.05.019.
2
Vaccine development for zoonotic viral diseases caused by positive‑sense single‑stranded RNA viruses belonging to the and families (Review).
Exp Ther Med. 2022 Nov 30;25(1):42. doi: 10.3892/etm.2022.11741. eCollection 2023 Jan.
3
Exposing cryptic epitopes on the Venezuelan equine encephalitis virus E1 glycoprotein prior to treatment with alphavirus cross-reactive monoclonal antibody allows blockage of replication early in infection.
Virology. 2022 Jan 2;565:13-21. doi: 10.1016/j.virol.2021.09.007. Epub 2021 Sep 28.
4
Pan-protective anti-alphavirus human antibodies target a conserved E1 protein epitope.
Cell. 2021 Aug 19;184(17):4414-4429.e19. doi: 10.1016/j.cell.2021.07.006.
5
Antibodies for Venezuelan Equine Encephalitis Virus Protect Embryoid Bodies from Chikungunya Virus.
Viruses. 2020 Feb 27;12(3):262. doi: 10.3390/v12030262.
6
Infection with mosquito-borne alphavirus induces selective loss of dopaminergic neurons, neuroinflammation and widespread protein aggregation.
NPJ Parkinsons Dis. 2019 Sep 13;5:20. doi: 10.1038/s41531-019-0090-8. eCollection 2019.
7
Approach to Strain Selection and the Propagation of Viral Stocks for Venezuelan Equine Encephalitis Virus Vaccine Efficacy Testing under the Animal Rule.
Viruses. 2019 Aug 31;11(9):807. doi: 10.3390/v11090807.
8
Current Understanding of the Molecular Basis of Venezuelan Equine Encephalitis Virus Pathogenesis and Vaccine Development.
Viruses. 2019 Feb 18;11(2):164. doi: 10.3390/v11020164.
9
Human-Like Neutralizing Antibodies Protect Mice from Aerosol Exposure with Western Equine Encephalitis Virus.
Viruses. 2018 Mar 24;10(4):147. doi: 10.3390/v10040147.

本文引用的文献

1
Entry Sites of Venezuelan and Western Equine Encephalitis Viruses in the Mouse Central Nervous System following Peripheral Infection.
J Virol. 2016 May 27;90(12):5785-96. doi: 10.1128/JVI.03219-15. Print 2016 Jun 15.
2
Fc-Receptor Interactions Regulate Both Cytotoxic and Immunomodulatory Therapeutic Antibody Effector Functions.
Cancer Immunol Res. 2015 Jul;3(7):704-13. doi: 10.1158/2326-6066.CIR-15-0120.
3
Stable, high-level expression of reporter proteins from improved alphavirus expression vectors to track replication and dissemination during encephalitic and arthritogenic disease.
J Virol. 2014 Feb;88(4):2035-46. doi: 10.1128/JVI.02990-13. Epub 2013 Dec 4.
4
Liposome-antigen-nucleic acid complexes protect mice from lethal challenge with western and eastern equine encephalitis viruses.
J Virol. 2014 Feb;88(3):1771-80. doi: 10.1128/JVI.02297-13. Epub 2013 Nov 20.
5
Induction of protection against leishmaniasis in susceptible BALB/c mice using simple DOTAP cationic nanoliposomes containing soluble Leishmania antigen (SLA).
Acta Trop. 2013 Dec;128(3):528-35. doi: 10.1016/j.actatropica.2013.07.021. Epub 2013 Aug 2.
6
A chimeric Sindbis-based vaccine protects cynomolgus macaques against a lethal aerosol challenge of eastern equine encephalitis virus.
Vaccine. 2013 Mar 1;31(11):1464-70. doi: 10.1016/j.vaccine.2013.01.014. Epub 2013 Jan 16.
7
Bioluminescent imaging and histopathologic characterization of WEEV neuroinvasion in outbred CD-1 mice.
PLoS One. 2013;8(1):e53462. doi: 10.1371/journal.pone.0053462. Epub 2013 Jan 2.
8
Immune interference in the setting of same-day administration of two similar inactivated alphavirus vaccines: eastern equine and western equine encephalitis.
Vaccine. 2012 Nov 26;30(50):7271-7. doi: 10.1016/j.vaccine.2012.09.049. Epub 2012 Sep 29.
9
Subunit vaccine formulations based on recombinant envelope proteins of Chikungunya virus elicit balanced Th1/Th2 response and virus-neutralizing antibodies in mice.
Virus Res. 2012 Aug;167(2):236-46. doi: 10.1016/j.virusres.2012.05.004. Epub 2012 May 17.
10
Factors affecting recombinant Western equine encephalitis virus glycoprotein production in the baculovirus system.
Protein Expr Purif. 2011 Dec;80(2):274-82. doi: 10.1016/j.pep.2011.08.002. Epub 2011 Aug 16.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验