Clark D G, Butterworth S T, Martin J G, Roderick H R, Bird M G
Shell Research Ltd., Sittingbourne, Kent, U.K.
Toxicol Ind Health. 1989 May;5(3):415-28. doi: 10.1177/074823378900500303.
A petroleum distillate--a high aromatic naphtha--consisting of a 50/50 blended mixture of equivalent products. SHELLSOL A* and SOLVESSO 100**, containing C9 isomers (75 percent) particularly trimethyl benzenes, was examined for systemic toxicity in rats by inhalation exposure. A preliminary 13-week inhalation study with SHELLSOL A had resulted in liver and kidney weight increases in female rats at the high (7400 mg/m3) and medium (3700 mg/m3) exposure levels, and a low grade anaemia in females at all exposure levels (7400, 3700 and 1800 mg/m3). The follow-up 12-month inhalation study in rats described here used atmosphere generated from the SHELLSOL A/SOLVESSO 100 blend of 1800, 900 and 450 mg/m3. Initial reduction in body weight gain occurred in both male and female rats at the higher exposures. Various statistically significant haematological changes were transiently seen in males up to six months, but were not considered biologically significant. High exposure male liver and kidney weights were increased at 6 and 12 months but, in the absence of histopathological changes, were considered to be physiological adaptive responses. No treatment-related histopathological abnormalities were found. It is concluded that chronic exposure to this high aromatic naphtha is without systemic toxicity in rats under the conditions of these studies.
一种石油馏出物——高芳烃石脑油，由等效产品SHELLSOL A*和SOLVESSO 100**按50/50混合而成，含有C9异构体（75%），尤其是三甲苯，通过吸入暴露对大鼠进行了全身毒性研究。一项为期13周的SHELLSOL A吸入初步研究表明，在高暴露水平（7400毫克/立方米）和中等暴露水平（3700毫克/立方米）下，雌性大鼠的肝脏和肾脏重量增加，并且在所有暴露水平（7400、3700和1800毫克/立方米）下雌性大鼠出现轻度贫血。此处描述的大鼠后续12个月吸入研究使用了由SHELLSOL A/SOLVESSO 100混合物产生的1800、900和450毫克/立方米的大气环境。在较高暴露水平下，雄性和雌性大鼠的体重增加最初均有所减少。雄性大鼠在长达6个月的时间里短暂出现了各种具有统计学意义的血液学变化，但被认为没有生物学意义。高暴露组雄性大鼠在6个月和12个月时肝脏和肾脏重量增加，但在没有组织病理学变化的情况下，被认为是生理适应性反应。未发现与治疗相关的组织病理学异常。结论是，在这些研究条件下，大鼠长期暴露于这种高芳烃石脑油不会产生全身毒性。
