Department of Surgery, Trinity Translational Medicine Institute (TTMI), Trinity College Dublin/St James' Hospital, Dublin, Ireland.
Department of Surgery, Trinity Translational Medicine Institute (TTMI), Trinity College Dublin/St James' Hospital, Dublin, Ireland.
Trends Endocrinol Metab. 2017 Jan;28(1):46-62. doi: 10.1016/j.tem.2016.08.004. Epub 2016 Sep 12.
There is compelling epidemiological evidence linking obesity to many tumours; however, the molecular mechanisms fuelling this association are not clearly understood. Emerging evidence links changes in the tumour microenvironment with the obese state, and murine and human studies highlight the relevance of adipose stromal cells (ASCs), including immune cells, both at remote fat depots, such as the omentum, as well as in peritumoural tissue. These obesity-associated changes have been implicated in several hallmarks of cancer, including the chronic inflammatory state and associated cell signalling, epithelial-to-mesenchymal transition (EMT), tumour-related fibrosis, angiogenesis, and genomic instability. Here, we present a summary of developments over the past 5 years, with particular focus on the tumour microenvironment in the obese state.
有强有力的流行病学证据将肥胖与许多肿瘤联系起来；然而，促进这种关联的分子机制尚不清楚。新出现的证据将肿瘤微环境的变化与肥胖状态联系起来，并且鼠类和人类研究强调了脂肪基质细胞 (ASC) 的相关性，包括免疫细胞，不仅在网膜等远处脂肪库中，而且在肿瘤周围组织中。这些与肥胖相关的变化与癌症的几个特征有关，包括慢性炎症状态和相关的细胞信号转导、上皮-间充质转化 (EMT)、肿瘤相关纤维化、血管生成和基因组不稳定性。在这里，我们总结了过去 5 年的发展情况，特别关注肥胖状态下的肿瘤微环境。
