Okoro B A, Kaine W N, Okeahialam T C
Department of Paediatrics, University of Nigeria Teaching Hospital, Enugu.
Trop Geogr Med. 1989 Apr;41(2):123-7.
A total of 4359 children with sickle cell anaemia were treated at the University of Nigeria Teaching Hospital, Enugu, Nigeria in an eight year period 1979-1986. Of this number 4 children with hypersplenism associated with intractable complaints were offered splenectomy as the treatment of choice. Following splenectomy they had improved haematological indices and general wellbeing, but splenectomy did not abolish abdominal or bone pain crises. This study emphasizes that though splenectomy could be of beneficial effect on carefully chosen cases of hypersplenism, it has not become a major form of therapy for the majority of children with sickle cell anaemia in Nigeria.
1979年至1986年的八年期间，尼日利亚埃努古的尼日利亚大学教学医院共治疗了4359名镰状细胞贫血患儿。其中，4名患有脾功能亢进并伴有顽固性症状的患儿接受了脾切除术作为首选治疗方法。脾切除术后，他们的血液学指标和总体健康状况有所改善，但脾切除术并未消除腹部或骨痛危象。这项研究强调，尽管脾切除术对精心挑选的脾功能亢进病例可能有益，但它尚未成为尼日利亚大多数镰状细胞贫血患儿的主要治疗方式。
