Aluoch J R
Unit of Infectious Diseases and Tropical Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands.
Trop Geogr Med. 1989 Apr;41(2):128-32.
During a study of clinical and laboratory features in 83 patients with sickle cell disease in the Netherlands, serum creatinine, sodium, potassium, uric acid and osmolality were determined and reported for 65: 39 with homozygous sickle cell (SS) disease, 5 with beta degrees thalassaemia (S beta degrees thal), with sickle cell beta + thalassaemia (S beta degrees + thal) and 17 with sickle cell haemoglobin C (SC) disease. Data on history of hyposthenuria was unreliable. Haematuria was reported in 6 (7%) of the 83 patients. Four of the six patients with a history of haematuria, two of whom had elevated creatinine levels, had SS disease. Lower mean levels of serum sodium and higher levels of serum potassium were observed in SS's than in the other genotypes (p less than 0.001). Hyperkalaemia of greater than 5 mmol/l was seen in 50% of SS disease cases and in 33% of paediatric SC disease cases. Some high potassium levels must be ascribed to in vitro haemolysis. The rate of hyperuricaemia ranged from 24% to 40% among the various genotypes. Clinical gout was not observed.
在一项针对荷兰83例镰状细胞病患者临床和实验室特征的研究中，测定并报告了65例患者的血清肌酐、钠、钾、尿酸和渗透压：39例为纯合镰状细胞（SS）病，5例为β0地中海贫血（Sβ0thal），5例为镰状细胞β +地中海贫血（Sβ + thal），17例为镰状细胞血红蛋白C（SC）病。关于低渗尿病史的数据不可靠。83例患者中有6例（7%）报告有血尿。有血尿病史的6例患者中，4例患有SS病，其中2例肌酐水平升高。与其他基因型相比，SS病患者的血清钠平均水平较低，血清钾水平较高（p < 0.001）。50%的SS病病例和33%的儿童SC病病例出现血钾高于5 mmol/l的高钾血症。一些高钾水平肯定归因于体外溶血。不同基因型的高尿酸血症发生率在24%至40%之间。未观察到临床痛风。
