Rhie Seonkyeong, Chae Kyu Young, Jo Heui Seung, Lee Kyu Hyung
Department of Pediatrics, CHA Bundang Medical Center, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-712, South Korea.
Ital J Pediatr. 2016 Sep 15;42(1):85. doi: 10.1186/s13052-016-0294-z.
The aim of this study was to evaluate the results of sleep-wake cycle monitoring using amplitude-integrated EEG (aEEG) and neuroimaging in newborn infants with a possible perinatal hypoxic insult, investigate the correlation between the findings, and determine the relevance of the findings to reasonably predict neurological outcome.
aEEG was recorded among newborn infants suspected of perinatal asphyxia between November, 2014 and June, 2015 in one neonatal intensive care unit facility. Brain imaging with serial ultrasonography and MRI when available were performed, and the infants were divided into two groups according to findings and potential neurological outcome: Group I (favorable findings) and Group II (severe findings such as high grade intraventricular hemorrhage, cerebral infarction or white matter injury). Established sleep-wake cycle times after birth was compared between the two groups.
Among 107 newborn infants, 85 subjects were classified as Group I and the remaining 22 subjects as Group II. The total number of aEEG sessions was 207 and recording time was 2,796 h with a mean of 14.43 ± 13.40 h per study. Estimated times of cyclicity were earlier in Group I (113.34 h, 95 % CI 82.31-144.37) as compared to Group II (504.39 h, 95 % CI 319.91-688.88; p < 0.001).
Delayed cyclicity on aEEG has a strong correlation with unfavorable brain neuroimages in newborns with possible perinatal asphyxia. If sleep-wake cycles do not appear during initial period after birth, follow-up aEEG studies are recommended.
Retrospectively registered Registration number: BD 2015-148 Name of registry: amplitude integrated EEG in neonate Date of registration: September 9, 2015.
本研究旨在评估使用振幅整合脑电图（aEEG）和神经影像学对可能存在围产期缺氧损伤的新生儿进行睡眠-觉醒周期监测的结果，研究各项结果之间的相关性，并确定这些结果对合理预测神经学结局的相关性。
2014年11月至2015年6月期间，在一个新生儿重症监护病房对疑似围产期窒息的新生儿进行aEEG记录。进行了连续超声检查和MRI脑成像（如有条件），并根据检查结果和潜在的神经学结局将婴儿分为两组：第一组（检查结果良好）和第二组（严重检查结果，如高级别脑室内出血、脑梗死或白质损伤）。比较两组出生后确定的睡眠-觉醒周期时间。
107名新生儿中，85名受试者被归类为第一组，其余22名受试者为第二组。aEEG检查总次数为207次，记录时间为2796小时，每项研究平均为14.43±13.40小时。与第二组（504.39小时，95%可信区间319.91-688.88；p<0.001）相比，第一组的估计周期性时间更早（113.34小时，95%可信区间82.31-144.37）。
aEEG上的周期性延迟与可能存在围产期窒息的新生儿不良脑影像学检查结果密切相关。如果出生后初期未出现睡眠-觉醒周期，建议进行后续aEEG研究。
回顾性注册 注册号：BD 2015-148 注册机构名称：新生儿振幅整合脑电图 注册日期：2015年9月9日。
