Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, 100083, China.
College of Life Science, Agricultural University of Hebei, Baoding, Hebei, 071001, China.
Sci Rep. 2016 Sep 16;6:33603. doi: 10.1038/srep33603.
Hemicelluloses are widely used to prepare gel materials because of their renewability, biodegradability, and biocompatibility. Here, molecular chain extension of hemicelluloses was obtained in a two-step process. Composite hydrogels were prepared via free radical graft copolymerization of crosslinked quaternized hemicelluloses (CQH) and acrylic acid (AA) in the presence of crosslinking agent N,N'-methylenebisacrylamide (MBA). This chain extension strategy significantly improved the mechanical performance of the resulting hydrogels. The crosslinking density, compression modulus, and swelling capacities of hydrogels were tuned by changing the AA/CQH and MBA/CQH contents. Moreover, the biocompatibility test suggests that the hemicelluloses-based hydrogels exhibited no toxicity to cells and allowed cell growth. Taken together, these properties demonstrated that the composite hydrogels have potential applications in the fields of water absorbents, cell culture, and other functional biomaterials.
半纤维素由于其可再生性、生物降解性和生物相容性而被广泛用于制备凝胶材料。在这里，通过两步法获得了半纤维素的分子链延伸。通过在交联剂 N,N'-亚甲基双丙烯酰胺（MBA）存在下，使交联季铵化半纤维素（CQH）和丙烯酸（AA）进行自由基接枝共聚，制备了复合水凝胶。这种链延伸策略显著提高了所得水凝胶的机械性能。通过改变 AA/CQH 和 MBA/CQH 的含量来调节水凝胶的交联密度、压缩模量和溶胀能力。此外，细胞相容性试验表明，基于半纤维素的水凝胶对细胞没有毒性，并且允许细胞生长。综上所述，这些特性表明复合水凝胶在吸水剂、细胞培养和其他功能生物材料等领域具有潜在的应用。
