Gardiner P R, Assoku R K, Whitelaw D D, Murray M
International Laboratory for Research on Animal Diseases, Nairobi, Kenya.
Vet Parasitol. 1989 Jun;31(3-4):187-97. doi: 10.1016/0304-4017(89)90069-1.
Infection of Ayrshire cattle with a stock of Trypanosoma vivax from the Galana Ranch, Kenya, resulted in an acute disease characterised by profound anaemia and haemorrhage, which reached maximum severity between 3 and 5 weeks after infection. Bleeding from the ears, nose and rectum occurred. At necropsy, petechial and ecchymotic haemorrhages were widespread, but were particularly severe in the gastrointestinal tract. In confirmation of the gross findings, congestion, haemorrhage and degenerative changes in most tissues and organs were found histologically. Thrombi were seen in the lymphatic vessels and clots of fibrin were present in the ventricles of the brain. The anaemia was a consequence of frank blood loss through haemorrhaging, exacerbated by erythrophagocytosis of deformed red blood cells, whose occurrence was indicative of microangiopathic changes. Animals were euthanised between 23 and 36 days after infection when they became recumbent with PCV values as low as 9%. There is no doubt that animals affected by this syndrome in the field would die within a few weeks of infection, if left untreated.
用来自肯尼亚加拉纳牧场的一批活跃锥虫感染艾尔夏牛，引发了一种急性疾病，其特征为严重贫血和出血，在感染后3至5周达到最严重程度。出现了耳朵、鼻子和直肠出血。尸检时，瘀点和瘀斑性出血广泛存在，但在胃肠道尤为严重。组织学检查证实了大体检查结果，发现大多数组织和器官有充血、出血和退行性变化。在淋巴管中可见血栓，脑室内有纤维蛋白凝块。贫血是出血导致明显失血的结果，变形红细胞的噬红细胞作用使其加重，这种情况的出现表明存在微血管病变。感染后23至36天，当动物卧地不起且红细胞压积值低至9%时，对其实施了安乐死。毫无疑问，在野外受此综合征影响的动物，如果不治疗，会在感染后几周内死亡。
