光氧化还原催化介导的甲基氟磺酰基二氟乙酸酯作为 CFCOR 自由基源的应用。
Photoredox Catalysis Mediated Application of Methyl Fluorosulfonyldifluoroacetate as the CFCOR Radical Source.
机构信息
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science , 345 Lingling Lu, Shanghai 200032, China.
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University , 2999 North Renmin Lu, Shanghai 201620, China.
出版信息
Org Lett. 2016 Oct 7;18(19):5130-5133. doi: 10.1021/acs.orglett.6b02580. Epub 2016 Sep 16.
A new application of trifluoromethylating reagent, methyl fluorosulfonyldifluoroacetate (FOSCFCOMe, Chen's reagent), as the carbomethoxydifluoromethylating reagent under visible light photoredox conditions is reported. The visible-light-induced reaction of FOSCFCOMe with unactivated alkenes, styrenes, or heteroarenes affords a variety of carbomethoxydifluoromethylated products.
报告了三氟甲基化试剂甲基氟磺酰基二氟乙酸酯（FOSCFCOMe，Chen 试剂）在可见光光氧化还原条件下作为羰甲氧二氟甲基化试剂的新应用。FOSCFCOMe 与未活化的烯烃、苯乙烯或杂芳烃在可见光诱导下反应，可得到多种羰甲氧二氟甲基化产物。
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