CAST基因中g.98535683A>G单核苷酸多态性对婆罗门牛（Bos indicus）及其与欧洲牛（Bos taurus）杂交后代肉质性状的影响。
Effect of the g.98535683A>G SNP in the CAST gene on meat traits of Nellore beef cattle (Bos indicus) and their crosses with Bos taurus.
作者信息
Enriquez-Valencia Cruz Elena, Pereira Guilherme Luis, Malheiros Jessica Moraes, de Vasconcelos Silva Josineudson Augusto I I, Albuquerque Lúcia Galvão, de Oliveira Henrique Nunes, Chardulo Luis Artur Loyola, Curi Rogério Abdallah
机构信息
Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP 14884-900, Brazil.
Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP 14884-900, Brazil.
出版信息
Meat Sci. 2017 Jan;123:64-66. doi: 10.1016/j.meatsci.2016.09.003. Epub 2016 Sep 10.
The objective of this study was to estimate allele frequencies of the g.98535683A>G:BTAU7 SNP in the CAST gene in different genetic groups of beef cattle produced in Brazil (Nellore and their crosses with Bos taurus), and to evaluate associations between this polymorphism and meat traits. Five hundred animals from six different genetic groups were genotyped and phenotyped for shear force (SF), myofibrillar fragmentation index (MFI), rib eye area, backfat thickness, and total lipids. Alleles A and G of the SNP were detected in all genetic groups and the frequency of A was higher than G. Significant association (P<0.05) was observed between the polymorphism and meat tenderness (SF and MFI), in which genotype AA exhibited the best values. These results demonstrate for the first time the occurrence of the studied SNP in a Zebu breed and its potential application to the genetic improvement of meat tenderness in the Nellore breed (Bos indicus) and its crosses with Bos taurus.
本研究的目的是估计巴西生产的不同肉牛遗传群体（内洛尔牛及其与欧洲牛的杂交后代）中CAST基因g.98535683A>G:BTAU7 SNP的等位基因频率，并评估该多态性与肉品质性状之间的关联。对来自六个不同遗传群体的500头动物进行了基因分型，并对剪切力（SF）、肌原纤维破碎指数（MFI）、眼肌面积、背膘厚度和总脂质进行了表型分析。在所有遗传群体中均检测到该SNP的A和G等位基因，且A的频率高于G。该多态性与肉嫩度（SF和MFI）之间存在显著关联（P<0.05），其中AA基因型表现出最佳值。这些结果首次证明了所研究的SNP在内洛尔牛品种中的存在及其在提高内洛尔牛（瘤牛）及其与欧洲牛杂交后代肉嫩度遗传改良中的潜在应用。
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