Azizi Gholamreza, Abolhassani Hassan, Asgardoon Mohammad Hosein, Alinia Tina, Yazdani Reza, Mohammadi Javad, Rezaei Nima, Ochs Hans D, Aghamohammadi Asghar
a Department of Laboratory Medicine , Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences , Karaj , Iran.
b Research Center for Immunodeficiencies, Pediatrics Center of Excellence , Children's Medical Center, Tehran University of Medical Sciences , Tehran , Iran.
Expert Rev Clin Immunol. 2017 Feb;13(2):101-115. doi: 10.1080/1744666X.2016.1224664. Epub 2016 Sep 16.
Common variable immunodeficiency (CVID) comprises a large heterogeneous group of patients with primary antibody deficiency. Areas covered: The affected patients are characterized by increased susceptibility to infections and low levels of serum immunoglobulin. However, enteropathy, granulomatous organ infiltrates, malignancy, inflammatory and autoimmune conditions are also prevalent. The concomitance of immunodeficiency and autoimmunity appears to be paradoxical and creates difficulties in the management of autoimmune complications affecting these patients. Expert commentary: The management of autoimmunity in patients with CVID requires special considerations because dysregulation and dysfunctions of the immune system along with persistent inflammation impair the process of diagnosis and treatment.
常见变异型免疫缺陷（CVID）包括一大组原发性抗体缺陷的异质性患者。涵盖领域：受影响的患者表现为易感染性增加和血清免疫球蛋白水平低。然而，肠病、肉芽肿性器官浸润、恶性肿瘤、炎症和自身免疫性疾病也很常见。免疫缺陷和自身免疫的并存似乎自相矛盾，给这些患者自身免疫并发症的管理带来困难。专家评论：CVID患者自身免疫的管理需要特殊考虑，因为免疫系统的失调和功能障碍以及持续炎症会损害诊断和治疗过程。
