慢性红细胞增多性骨髓增殖症（迪古列尔莫综合征）中的精氨酸甲基转移酶活性。

Arginine methyltransferase activity in chronic erythremic myelosis (Diguglielmo syndrome).

作者信息

Kass L, Munster D

出版信息

Biochim Biophys Acta. 1978 Jun 9;524(2):497-500. doi: 10.1016/0005-2744(78)90189-4.

Abstract

Activity of S-adenosylmethionine-dependent arginine methyltransferase was substantially higher in sonicated bone marrow samples from 6 patients with chronic erythremic myelosis than in bone marrow from 3 patients with untreated pernicious anemia, 2 patients with autoimmune hemolytic anemia, and 4 normal persons. Increased activity of this enzyme may be one of the factors contributing to the pathogenesis fo methylated arginines in histones of erythroblasts from patients with chronic erythremic myelosis.

摘要

6例慢性红细胞增多性骨髓增殖症患者经超声处理的骨髓样本中，S-腺苷甲硫氨酸依赖性精氨酸甲基转移酶的活性显著高于3例未经治疗的恶性贫血患者、2例自身免疫性溶血性贫血患者的骨髓以及4名正常人的骨髓。该酶活性增加可能是导致慢性红细胞增多性骨髓增殖症患者成红细胞组蛋白中精氨酸甲基化发病机制的因素之一。