Juzeniene Asta, Grigalavicius Mantas, Juraleviciute Marina, Grant William B
Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N-0310 Oslo, Norway.
Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N-0310 Oslo, Norway.
Clin Dermatol. 2016 Sep-Oct;34(5):548-55. doi: 10.1016/j.clindermatol.2016.05.004. Epub 2016 May 20.
The skin is the site for the photosynthesis of vitamin D and is a target tissue for the active metabolite of vitamin D. An increasing body of evidence indicates that vitamin D produced during phototherapy may be responsible for the positive effects observed during treatment of some skin diseases. Topical or oral application of vitamin D derivatives are used alone or with phototherapy. This paper reviews what is known about the use of phototherapy to enhance vitamin D levels, the use of vitamin D analogues with phototherapy, the efficacy of combination therapies, and controversies regarding some of the outcomes. Vitamin D can play a beneficial role in treating psoriasis, even though the exact role of vitamin D in the pathogenesis and severity of psoriasis remains unclear. The role of vitamin D in vitiligo, atopic dermatitis, polymorphic light eruption, and mycosis fungoides must be further investigated.
皮肤是维生素D合成的场所，也是维生素D活性代谢产物的靶组织。越来越多的证据表明，光疗过程中产生的维生素D可能是某些皮肤病治疗期间观察到的积极效果的原因。维生素D衍生物的局部或口服应用可单独使用或与光疗联合使用。本文综述了关于利用光疗提高维生素D水平、光疗联合使用维生素D类似物、联合治疗的疗效以及一些结果相关争议的已知情况。维生素D在治疗银屑病中可发挥有益作用，尽管维生素D在银屑病发病机制和严重程度中的确切作用仍不清楚。维生素D在白癜风、特应性皮炎、多形性日光疹和蕈样肉芽肿中的作用必须进一步研究。
