银屑病：从发病机制到基于药理学和纳米技术的治疗方法。

Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain.

Institute of Nanoscience and Nanotechnology, Universitat de Barcelona, 08028 Barcelona, Spain.

Int J Mol Sci. 2021 May 7;22(9):4983. doi: 10.3390/ijms22094983.

Research in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the development of new pharmacological and technological treatment approaches. In this review, we discuss the molecular mechanisms behind the pathological features of psoriasis, also addressing the currently available treatments and novel therapies that are under clinical trials. Innovative therapies developed over the last 10 years have been researched. In this area, advantages of nanotechnological approaches to provide an effective drug concentration in the disease site are highlighted, together with microneedles as innovative candidates for drug delivery systems in psoriasis and other inflammatory chronic skin diseases.

近年来，炎症性皮肤病（如皮炎和银屑病）的发病机制研究取得了一些相关突破。年龄相关因素、性别和这些多因素疾病的遗传易感性的认识，为新的药理学和技术治疗方法的发展提供了帮助。在这篇综述中，我们讨论了银屑病病理特征背后的分子机制，还讨论了目前可用的治疗方法和正在临床试验中的新疗法。研究了过去 10 年中开发的创新疗法。在这一领域，突出了纳米技术方法在疾病部位提供有效药物浓度的优势，以及微针作为银屑病和其他炎症性慢性皮肤病药物输送系统的创新候选物。