Bukhman V M, Lichinitser M R, Svet-Moldavskiĭ G Ia, Mkheidze D M
Biull Eksp Biol Med. 1978 Mar;85(3):340-3.
Oral administration of deoxycytidine simultaneously with intraperitoneal injections of toxic doses of cytosine arabinosidetomice with advanced L1210 leukemia diminished the toxic effects preventing drug death of these mice. They developed a marked antitumor effect. The mean survival time of these mice was considerably extended as compared to that of untreated animals or those given one of these drugs alone. At the optimum schedule of treatment about 23% of the mice survived over 60 days. Deoxycytidine protection reduced the antileukemic effect of cytosine arabinoside administered in nontoxic doses. The deoxycytidine plus cytosine arabinose combination was ineffective in the treatment of transplantable myeloid leukemia in mice.
对患有晚期L1210白血病的小鼠同时口服脱氧胞苷并腹腔注射毒性剂量的阿糖胞苷，可减轻毒性作用，防止这些小鼠因药物死亡。它们产生了显著的抗肿瘤作用。与未治疗的动物或单独给予其中一种药物的动物相比，这些小鼠的平均存活时间显著延长。在最佳治疗方案下，约23%的小鼠存活超过60天。脱氧胞苷的保护作用降低了无毒剂量阿糖胞苷的抗白血病作用。脱氧胞苷加阿糖胞苷的组合对小鼠可移植性髓性白血病的治疗无效。
