Barkhotkina M F, Bukhman V M
Biull Eksp Biol Med. 1980 Oct;90(10):472-3.
Intraperitoneal administration of cytosine arabinoside (araC) in a dose of 160 mg/kg/day for two days to BALB/c female mice with the advanced Rauscher erythroblastic leukemia led to a 6 fold decrease in the spleen weight and changed the spleen cytological content towards normal on the third day after therapy discontinuation. However, advanced lethal toxicity that developed at the same time resulted in the death of mice. Simultaneous administration of araC and deoxycytidine (CdR) per os in doses 3 times as high as doses of araC decreased the antitumor and toxic effects of araC. CdR protected the neoplastic erythropoietic cells rather than lymphoid cells against the toxic effect of araC.
对患有晚期劳舍尔成红细胞白血病的BALB/c雌性小鼠腹腔注射剂量为160mg/kg/天的阿糖胞苷（araC），持续两天，这导致脾脏重量在停药后第三天下降了6倍，并使脾脏细胞内容物向正常状态转变。然而，同时出现的严重致命毒性导致小鼠死亡。以比阿糖胞苷剂量高3倍的剂量同时经口给予阿糖胞苷和脱氧胞苷（CdR），可降低阿糖胞苷的抗肿瘤和毒性作用。CdR保护肿瘤性红细胞生成细胞而非淋巴细胞免受阿糖胞苷的毒性作用。
