De Masi Roberto, Orlando Stefania, Conte Aldo, Pasca Sergio, Scarpello Rocco, Spagnolo Pantaleo, Muscella Antonella, De Donno Antonella
Laboratory of Neuroproteomics, Multiple Sclerosis Center, "F. Ferrari" Hospital, Casarano-Lecce, Italy; Multiple Sclerosis Center, "F. Ferrari" Hospital, Casarano-Lecce, Italy; Complex Operative Neurology-Stroke Unit, "F. Ferrari" Hospital, Casarano-Lecce, Italy.
Laboratory of Neuroproteomics, Multiple Sclerosis Center, "F. Ferrari" Hospital, Casarano-Lecce, Italy; Department of Biological and Environmental Sciences and Technologies, Laboratory of Hygiene, University of the Salento-Lecce, Italy.
Ultrasound Med Biol. 2016 Dec;42(12):3037-3042. doi: 10.1016/j.ultrasmedbio.2016.07.018. Epub 2016 Sep 15.
Optic nerve sheath diameter quantification by transbulbar B-mode sonography is a recently validated technique, but its clinical relevance in relapse-free multiple sclerosis patients remains unexplored. In an open-label, comparative, cross-sectional study, we aimed to assess possible differences between patients and healthy controls in terms of optic nerve sheath diameter and its correlation with clinical/paraclinical parameters in this disease. Sixty unselected relapse-free patients and 35 matched healthy controls underwent transbulbar B-mode sonography. Patients underwent routine neurologic examination, brain magnetic resonance imaging and visual evoked potential tests. The mean optic nerve sheath diameter 3 and 5 mm from the eyeball was 22-25% lower in patients than controls and correlated with the Expanded Disability Status Scale (r = -0.34, p = 0.048, and r = -0.32, p = 0.042, respectively). We suggest that optic nerve sheath diameter quantified by transbulbar B-mode sonography should be included in routine assessment of the disease as an extension of the neurologic examination.
经眼球B超测量视神经鞘直径是一项最近得到验证的技术，但在无复发的多发性硬化症患者中的临床意义仍未得到探索。在一项开放标签、比较性横断面研究中，我们旨在评估患者与健康对照在视神经鞘直径方面的可能差异，以及该直径与该病临床/副临床参数的相关性。60例未经挑选的无复发患者和35例匹配的健康对照接受了经眼球B超检查。患者接受了常规神经学检查、脑磁共振成像和视觉诱发电位测试。距眼球3毫米和5毫米处的平均视神经鞘直径，患者比对照低22%-25%，且与扩展残疾状态量表相关（分别为r = -0.34，p = 0.048，以及r = -0.32，p = 0.042）。我们建议，经眼球B超测量的视神经鞘直径应纳入该病的常规评估，作为神经学检查的一项扩展内容。
